Institut für Organische Chemie, Universität Stuttgart, Stuttgart, Germany.
Chemistry. 2011 Aug 1;17(32):8807-9. doi: 10.1002/chem.201101073. Epub 2011 Jul 6.
Second nature: Starting from shelf-stable aryl esters and thiols, a variety of carboxylic acid esters were transformed into the corresponding thioesters with no racemization of labile stereocenters. The method was successfully applied in a native chemical-ligation-type peptide formation, which suggests that the thiol may act as a co-catalyst for future 1,2-additions of pronucleophiles to carboxylic esters.
从货架稳定的芳基酯和硫醇出发，各种羧酸酯在不发生不稳定手性中心外消旋的情况下转化为相应的硫酯。该方法成功地应用于天然化学连接型肽的形成，这表明硫醇可能作为未来亲核试剂对羧酸酯的 1,2-加成的共催化剂。
