胶质母细胞瘤：第一部分。现状。
Glioblastoma: Part I. Current state of affairs.
作者信息
Salacz Michael E, Watson Kenneth R, Schomas David A
机构信息
Saint Luke's Brain Tumor Center, Kansas City, MO, USA.
出版信息
Mo Med. 2011 May-Jun;108(3):187-94.
Abstract
Although uncommon, "brain cancer" is one of the most feared diseases that afflict human beings. While still regarded as one of the most deadly forms of primary brain neoplasm, recent advances in the treatment of glioblastoma (GBM) have offered new hope for patients, families, and clinicians. In the first part of this two-part review, we will focus on the multidisciplinary advances that have established the current treatment approach in the management of GBM. In the second part of this review, ongoing research will be presented including current clinical trials as well as some of the newer technologies that are forming the promise of the future.
摘要
尽管并不常见，但“脑癌”是困扰人类的最令人恐惧的疾病之一。虽然胶质母细胞瘤（GBM）仍被视为原发性脑肿瘤最致命的形式之一，但近年来GBM治疗方面的进展为患者、家属和临床医生带来了新希望。在这篇分两部分的综述的第一部分中，我们将重点关注确立当前GBM治疗方法的多学科进展。在综述的第二部分，将介绍正在进行的研究，包括当前的临床试验以及一些有望引领未来的新技术。
相似文献
1
Glioblastoma: Part I. Current state of affairs.胶质母细胞瘤：第一部分。现状。
Mo Med. 2011 May-Jun;108(3):187-94.
2
Glioblastoma. Part II: Future directions.胶质母细胞瘤。第二部分：未来方向。
Mo Med. 2011 Jul-Aug;108(4):289-91.
3
Glioblastoma multiforme: evidence-based approach to therapy.多形性胶质母细胞瘤：基于证据的治疗方法。
Expert Rev Anticancer Ther. 2007 Dec;7(12 Suppl):S23-7. doi: 10.1586/14737140.7.12s.S23.
4
Recent and ongoing clinical trials in glioblastoma.近期及正在进行的胶质母细胞瘤临床试验。
Clin Adv Hematol Oncol. 2018 Jul;16(7):480-483.
5
Does gender matter in glioblastoma?性别在胶质母细胞瘤中重要吗？
Clin Transl Oncol. 2011 Oct;13(10):737-41. doi: 10.1007/s12094-011-0725-7.
6
Prognosis factors of survival time in patients with glioblastoma multiforme: a multivariate analysis of 340 patients.多形性胶质母细胞瘤患者生存时间的预后因素：340例患者的多变量分析
Acta Neurochir (Wien). 2007 Mar;149(3):245-52; discussion 252-3. doi: 10.1007/s00701-006-1092-y. Epub 2007 Feb 2.
7
Survival improvements with adjuvant therapy in patients with glioblastoma.胶质母细胞瘤患者辅助治疗后的生存改善情况。
ANZ J Surg. 2018 Mar;88(3):196-201. doi: 10.1111/ans.14153. Epub 2017 Sep 18.
8
Clinical features associated with the efficacy of chemotherapy in patients with glioblastoma (GBM): a surveillance, epidemiology, and end results (SEER) analysis.与胶质母细胞瘤（GBM）患者化疗疗效相关的临床特征：监测、流行病学和最终结果（SEER）分析。
BMC Cancer. 2021 Jan 19;21(1):81. doi: 10.1186/s12885-021-07800-0.
9
Concomitant chemoradiotherapy followed by adjuvant temozolomide improves survival in glioblastoma multiforme.同步放化疗后辅助使用替莫唑胺可提高多形性胶质母细胞瘤患者的生存率。
Curr Neurol Neurosci Rep. 2005 May;5(3):167-8. doi: 10.1007/s11910-005-0043-y.
10
Multiple microsurgical resections for repeated recurrence of glioblastoma multiforme.多次显微手术切除治疗复发性多形性胶质母细胞瘤。
Am J Clin Oncol. 2013 Jun;36(3):261-8. doi: 10.1097/COC.0b013e3182467bb1.
引用本文的文献
1
Zika Virus: A Neurotropic Warrior against High-Grade Gliomas-Unveiling Its Potential for Oncolytic Virotherapy.寨卡病毒：一种对抗高级别胶质瘤的嗜神经“战士”——揭示其溶瘤病毒疗法的潜力
Viruses. 2024 Apr 3;16(4):561. doi: 10.3390/v16040561.
2
Differentiation of glioblastoma and primary central nervous system lymphomas using multiparametric diffusion and perfusion magnetic resonance imaging.利用多参数扩散和灌注磁共振成像鉴别胶质母细胞瘤和原发性中枢神经系统淋巴瘤
Biomed Rep. 2023 Sep 22;19(5):82. doi: 10.3892/br.2023.1664. eCollection 2023 Nov.
3
Overexpression of FZD7 promotes glioma cell proliferation by upregulating TAZ.FZD7的过表达通过上调TAZ促进胶质瘤细胞增殖。
Oncotarget. 2016 Dec 27;7(52):85987-85999. doi: 10.18632/oncotarget.13292.
4
Glioblastoma: Overview of Disease and Treatment.胶质母细胞瘤：疾病与治疗概述
Clin J Oncol Nurs. 2016 Oct 1;20(5 Suppl):S2-8. doi: 10.1188/16.CJON.S1.2-8.
5
Novel anti-glioblastoma agents and therapeutic combinations identified from a collection of FDA approved drugs.从美国食品和药物管理局批准的药物集中鉴定出新型抗神经胶质瘤药物和治疗组合。
J Transl Med. 2014 Jan 17;12:13. doi: 10.1186/1479-5876-12-13.
6
BMP2 sensitizes glioblastoma stem-like cells to Temozolomide by affecting HIF-1α stability and MGMT expression.BMP2 通过影响 HIF-1α 稳定性和 MGMT 表达使神经胶质瘤干细胞样细胞对替莫唑胺敏感。
Cell Death Dis. 2012 Oct 18;3(10):e412. doi: 10.1038/cddis.2012.153.
7
Breast cancer resistance protein (BCRP/ABCG2) localises to the nucleus in glioblastoma multiforme cells.乳腺癌耐药蛋白（BCRP/ABCG2）定位于多形性胶质母细胞瘤细胞的细胞核中。
Xenobiotica. 2012 Aug;42(8):748-55. doi: 10.3109/00498254.2012.662726. Epub 2012 Mar 8.
8
Nanoparticles of carbon allotropes inhibit glioblastoma multiforme angiogenesis in ovo.碳同素异形体纳米粒子抑制鸡胚中多形性胶质母细胞瘤血管生成。
Int J Nanomedicine. 2011;6:3041-8. doi: 10.2147/IJN.S25528. Epub 2011 Nov 25.
本文引用的文献
1
Multiple craniotomies in the management of multifocal and multicentric glioblastoma. Clinical article.多部位和多中心性胶质母细胞瘤的多次开颅手术治疗。临床文章。
J Neurosurg. 2011 Mar;114(3):576-84. doi: 10.3171/2010.6.JNS091326. Epub 2010 Aug 6.
2
Prevalence estimates for primary brain tumors in the United States by age, gender, behavior, and histology.美国原发性脑肿瘤的年龄、性别、行为和组织学分布的流行率估计。
Neuro Oncol. 2010 Jun;12(6):520-7. doi: 10.1093/neuonc/nop066. Epub 2010 Feb 8.
3
Phase II trial of continuous dose-intense temozolomide in recurrent malignant glioma: RESCUE study.复发恶性胶质瘤连续剂量密集替莫唑胺的 II 期试验：RESCUE 研究。
J Clin Oncol. 2010 Apr 20;28(12):2051-7. doi: 10.1200/JCO.2009.26.5520. Epub 2010 Mar 22.
4
Phase II trial of low-dose continuous (metronomic) treatment of temozolomide for recurrent glioblastoma.替莫唑胺低剂量连续（节拍式）治疗复发性胶质母细胞瘤的 II 期临床试验。
Neuro Oncol. 2010 Mar;12(3):289-96. doi: 10.1093/neuonc/nop030. Epub 2010 Jan 11.
5
MGMT promoter methylation is predictive of response to radiotherapy and prognostic in the absence of adjuvant alkylating chemotherapy for glioblastoma.MGMT 启动子甲基化可预测胶质母细胞瘤在无辅助烷化化疗的情况下对放疗的反应和预后。
Neuro Oncol. 2010 Feb;12(2):116-21. doi: 10.1093/neuonc/nop020. Epub 2009 Dec 14.
6
Phase III study of enzastaurin compared with lomustine in the treatment of recurrent intracranial glioblastoma.恩杂鲁胺对比洛莫司汀治疗复发性颅内胶质母细胞瘤的 III 期研究。
J Clin Oncol. 2010 Mar 1;28(7):1168-74. doi: 10.1200/JCO.2009.23.2595. Epub 2010 Feb 1.
7
Current developments in the radiotherapy approach to elderly and frail patients with glioblastoma multiforme.多形性胶质母细胞瘤老年和虚弱患者放射治疗方法的最新进展。
Expert Rev Anticancer Ther. 2009 Nov;9(11):1643-50. doi: 10.1586/era.09.128.
8
Mobile phone use and risk of tumors: a meta-analysis.手机使用与肿瘤风险：一项荟萃分析。
J Clin Oncol. 2009 Nov 20;27(33):5565-72. doi: 10.1200/JCO.2008.21.6366. Epub 2009 Oct 13.
9
Biopsy versus resection in the management of malignant gliomas: a systematic review and meta-analysis.活检与切除在恶性胶质瘤治疗中的比较：系统评价和荟萃分析。
J Neurosurg. 2010 May;112(5):1020-32. doi: 10.3171/2009.7.JNS09758.
10
Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma.贝伐单抗单药及联合伊立替康治疗复发性胶质母细胞瘤。
J Clin Oncol. 2009 Oct 1;27(28):4733-40. doi: 10.1200/JCO.2008.19.8721. Epub 2009 Aug 31.
Zotero 插件