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胶质母细胞瘤:第一部分。现状。

Glioblastoma: Part I. Current state of affairs.

作者信息

Salacz Michael E, Watson Kenneth R, Schomas David A

机构信息

Saint Luke's Brain Tumor Center, Kansas City, MO, USA.

出版信息

Mo Med. 2011 May-Jun;108(3):187-94.

PMID:21736079
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6188294/
Abstract

Although uncommon, "brain cancer" is one of the most feared diseases that afflict human beings. While still regarded as one of the most deadly forms of primary brain neoplasm, recent advances in the treatment of glioblastoma (GBM) have offered new hope for patients, families, and clinicians. In the first part of this two-part review, we will focus on the multidisciplinary advances that have established the current treatment approach in the management of GBM. In the second part of this review, ongoing research will be presented including current clinical trials as well as some of the newer technologies that are forming the promise of the future.

摘要

尽管并不常见,但“脑癌”是困扰人类的最令人恐惧的疾病之一。虽然胶质母细胞瘤(GBM)仍被视为原发性脑肿瘤最致命的形式之一,但近年来GBM治疗方面的进展为患者、家属和临床医生带来了新希望。在这篇分两部分的综述的第一部分中,我们将重点关注确立当前GBM治疗方法的多学科进展。在综述的第二部分,将介绍正在进行的研究,包括当前的临床试验以及一些有望引领未来的新技术。

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本文引用的文献

1
Multiple craniotomies in the management of multifocal and multicentric glioblastoma. Clinical article.多部位和多中心性胶质母细胞瘤的多次开颅手术治疗。临床文章。
J Neurosurg. 2011 Mar;114(3):576-84. doi: 10.3171/2010.6.JNS091326. Epub 2010 Aug 6.
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Prevalence estimates for primary brain tumors in the United States by age, gender, behavior, and histology.美国原发性脑肿瘤的年龄、性别、行为和组织学分布的流行率估计。
Neuro Oncol. 2010 Jun;12(6):520-7. doi: 10.1093/neuonc/nop066. Epub 2010 Feb 8.
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Phase II trial of continuous dose-intense temozolomide in recurrent malignant glioma: RESCUE study.复发恶性胶质瘤连续剂量密集替莫唑胺的 II 期试验:RESCUE 研究。
J Clin Oncol. 2010 Apr 20;28(12):2051-7. doi: 10.1200/JCO.2009.26.5520. Epub 2010 Mar 22.
4
Phase II trial of low-dose continuous (metronomic) treatment of temozolomide for recurrent glioblastoma.替莫唑胺低剂量连续(节拍式)治疗复发性胶质母细胞瘤的 II 期临床试验。
Neuro Oncol. 2010 Mar;12(3):289-96. doi: 10.1093/neuonc/nop030. Epub 2010 Jan 11.
5
MGMT promoter methylation is predictive of response to radiotherapy and prognostic in the absence of adjuvant alkylating chemotherapy for glioblastoma.MGMT 启动子甲基化可预测胶质母细胞瘤在无辅助烷化化疗的情况下对放疗的反应和预后。
Neuro Oncol. 2010 Feb;12(2):116-21. doi: 10.1093/neuonc/nop020. Epub 2009 Dec 14.
6
Phase III study of enzastaurin compared with lomustine in the treatment of recurrent intracranial glioblastoma.恩杂鲁胺对比洛莫司汀治疗复发性颅内胶质母细胞瘤的 III 期研究。
J Clin Oncol. 2010 Mar 1;28(7):1168-74. doi: 10.1200/JCO.2009.23.2595. Epub 2010 Feb 1.
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Current developments in the radiotherapy approach to elderly and frail patients with glioblastoma multiforme.多形性胶质母细胞瘤老年和虚弱患者放射治疗方法的最新进展。
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