Maisel A S, Harris T, Rearden C A, Michel M C
Department of Medicine, University of California, San Diego.
Circulation. 1990 Dec;82(6):2003-10. doi: 10.1161/01.cir.82.6.2003.
Dynamic exercise increases the number of beta-adrenergic receptors in mixed lymphocytes by a mechanism that is incompletely understood. In a set of in vivo studies, we have investigated the effects of dynamic exercise on the subset distribution of circulating lymphocytes and on the number of beta-adrenergic receptors in each of these subsets in two groups of patients. In healthy subjects, exercise increased plasma norepinephrine and epinephrine and caused lymphocytosis. Whereas the number of Thelper cells increased only modestly, the number of Tsuppressor/cytotoxic and natural killer cells more than tripled. The number of beta-adrenergic receptors varied among subsets but was not significantly altered by dynamic exercise in any subset except natural killer cells (35% increase, p = 0.0302). In a group of patients with congestive heart failure, dynamic exercise increased plasma norepinephrine but did not alter plasma epinephrine and did not cause significant lymphocytosis. We did not detect any significant alterations of circulating leukocyte subsets or beta-adrenergic receptors in any of these subsets after exercise. A combined analysis of healthy patients and heart failure patients revealed a significant correlation between increases in plasma epinephrine and increases in circulating lymphocytes. We conclude that the exercise-induced increase in beta-adrenergic receptors of mixed lymphocytes is predominantly caused by a redistribution of circulating cell subsets that differ in their beta-adrenergic receptor number. This appears to be mediated by epinephrine rather than norepinephrine.
动态运动通过一种尚未完全了解的机制增加混合淋巴细胞中β-肾上腺素能受体的数量。在一组体内研究中，我们调查了动态运动对两组患者循环淋巴细胞亚群分布以及这些亚群中每个亚群β-肾上腺素能受体数量的影响。在健康受试者中，运动增加了血浆去甲肾上腺素和肾上腺素水平，并导致淋巴细胞增多。辅助性T细胞数量仅适度增加，而抑制性/细胞毒性T细胞和自然杀伤细胞的数量增加了两倍多。β-肾上腺素能受体数量在各亚群中有所不同，但除自然杀伤细胞外（增加35%，p = 0.0302），动态运动在任何亚群中均未显著改变其数量。在一组充血性心力衰竭患者中，动态运动增加了血浆去甲肾上腺素水平，但未改变血浆肾上腺素水平，也未引起显著的淋巴细胞增多。运动后，我们未在任何这些亚群中检测到循环白细胞亚群或β-肾上腺素能受体有任何显著变化。对健康患者和心力衰竭患者的综合分析显示，血浆肾上腺素增加与循环淋巴细胞增加之间存在显著相关性。我们得出结论，运动诱导的混合淋巴细胞β-肾上腺素能受体增加主要是由循环细胞亚群的重新分布引起的，这些亚群的β-肾上腺素能受体数量不同。这似乎是由肾上腺素而非去甲肾上腺素介导的。
