Department of Neurology, University of Iowa College of Medicine, 200 Hawkins Drive, 2192 RCP, Iowa City, IA 52242, USA.
J Cogn Neurosci. 2011 Dec;23(12):3862-73. doi: 10.1162/jocn_a_00089. Epub 2011 Jul 7.
Medial temporal lobe (MTL) contributions to the brief maintenance of visual representations were evaluated by studying a group of patients with MTL damage. Eye movements of patients and healthy comparison subjects were tracked while performing a visual search for a target among complex stimuli of varying similarity to that target. Despite the task having no imposed delays, patients were impaired behaviorally, and eye movement measures showed abnormally rapid degradation of target representations in the patients. Eye movement data showed a modulation of the duration of fixations as a function of the similarity of fixated array lures to the target, but the effect was attenuated in patients during long fixation paths away from the sample target. This effect manifested despite patients' shorter searches and more frequent fixations of the sample target. Novel techniques provided unique insight into visual representation without healthy MTL, which may support maintenance of information through hippocampal-dependent relational binding.
通过研究一组患有颞叶内侧损伤的患者，评估了颞叶内侧对视觉表象短暂维持的贡献。在进行视觉搜索以在与目标相似的复杂刺激中寻找目标时，跟踪了患者和健康对照组的眼动。尽管该任务没有强制延迟，但患者的行为受到损害，眼动测量结果显示患者的目标表象异常迅速退化。眼动数据显示注视持续时间的调制作为注视数组诱饵与目标相似性的函数，但在远离样本目标的长注视路径中，患者的效果减弱。尽管患者的搜索时间更短，并且更频繁地注视样本目标，但仍出现了这种效果。新的技术为没有健康的内侧颞叶的视觉表象提供了独特的见解，这可能通过海马依赖的关系绑定来支持信息的维持。
