Ehsanipoor Robert M, Arora Neelu, Lagrew David C, Wing Deborah A, Chung Judith H
Department of Obstetrics and Gynecology, University of California, Irvine, Orange, CA, USA.
J Matern Fetal Neonatal Med. 2012 Jun;25(6):658-61. doi: 10.3109/14767058.2011.584924. Epub 2011 Jul 8.
To compare latency period, infectious morbidity, neonatal morbidity and neonatal mortality in twin versus singleton pregnancies complicated by preterm premature rupture of membranes (PPROM) remote from term.
A retrospective, matched cohort study comparing 41 twin and 82 singleton pregnancies complicated by PPROM between 24-0/7 and 31-6/7 weeks' gestation. The data were obtained by reviewing maternal and neonatal charts.
The median latency periods were 3.6 days (interquartile range 1.5-13.9 days) for twins and 6.2 days (interquartile range 2.9-11.8 days) for singletons (p = 0.86). Twins were less likely to be complicated by clinical chorioamnionitis when compared with singletons (4/41 [9.8%] vs. 19/82 [23.2%], relative risk [RR] 0.42, 95% confidence interval [CI] 0.18-0.96). Histological evidence of chorioamnionitis was also lower in twins compared with singletons (14/39 [35.9%] vs. 46/68 [67.7%], RR 0.56, 95% CI, 0.34-0.92). These differences persisted after adjusting for race, insurance status, latency period and route of delivery. Neonatal morbidity and mortality rates were similar between the two groups.
There was not a statistically significant difference in the latency periods for twin and singleton pregnancies complicated by PPROM. Clinical chorioamnionitis and histological evidence of infection were significantly less common in twins compared with singletons.
比较双胎妊娠与单胎妊娠合并晚期未足月胎膜早破（PPROM）时的潜伏期、感染发病率、新生儿发病率及新生儿死亡率。
一项回顾性匹配队列研究，比较41例双胎妊娠和82例单胎妊娠，这些妊娠均在孕24⁺⁰/₇至31⁺⁶/₇周合并PPROM。数据通过查阅产妇和新生儿病历获得。
双胎妊娠的中位潜伏期为3.6天（四分位间距1.5 - 13.9天），单胎妊娠为6.2天（四分位间距2.9 - 11.8天）（p = 0.86）。与单胎妊娠相比，双胎妊娠发生临床绒毛膜羊膜炎的可能性较小（4/41 [9.8%] 对19/82 [23.2%]，相对危险度[RR] 0.42，95%置信区间[CI] 0.18 - 0.96）。双胎妊娠绒毛膜羊膜炎的组织学证据也低于单胎妊娠（14/39 [35.9%] 对46/68 [67.7%]，RR 0.56，95% CI 0.34 - 0.92）。在对种族、保险状况、潜伏期和分娩途径进行校正后，这些差异仍然存在。两组的新生儿发病率和死亡率相似。
双胎妊娠与单胎妊娠合并PPROM时的潜伏期无统计学显著差异。与单胎妊娠相比，双胎妊娠临床绒毛膜羊膜炎和感染的组织学证据明显较少见。
