Department of Stomatology, Division of Periodontics, School of Dentistry, University of Sao Paulo, Brazil.
J Clin Periodontol. 2011 Oct;38(10):902-14. doi: 10.1111/j.1600-051X.2011.01761.x. Epub 2011 Jul 7.
The aim of this systematic review was to evaluate whether maternal periodontal disease treatment (MPDT) can reduce the incidence of preterm birth (PB) and/or low birth weight (LBW).
The Cochrane Central Register of Controlled Trials, MEDLINE and EMBASE were searched for entries up to October 2010 without restrictions regarding the language of publication. Only randomized-controlled clinical trials (RCTs) that evaluated the effect of MPDT on birth term and birth weight were included. The search was conducted by two independent reviewers and random-effects meta-analyses were conducted methodically.
Thirteen RCTs provided data, but only five trials were considered to be at a low risk of bias. The results of eight studies (61.5%) showed that MPDT may reduce the incidence of PB and/or LBW. However, the results of all meta-analyses showed contrasting results for PB [RR: 0.88 (95% CI: 0.72, 1.09)], LBW [RR: 0.78 (95% CI: 0.53, 1.17)] and PB/LBW [RR: 0.52 (95% CI: 0.08, 3.31)].
The results of this review show that MPDT did not decrease the risk of PB and/or LBW; however, the influence of specific aspects that were not investigated (disease diagnosis, extension and severity and the success of MPDT) should be evaluated by future RCTs.
本系统评价旨在评估母体牙周病治疗（MPDT）是否可以降低早产（PB）和/或低出生体重（LBW）的发生率。
对 Cochrane 对照试验中心注册库、MEDLINE 和 EMBASE 进行检索，截至 2010 年 10 月，对出版语言不加限制。仅纳入评价 MPDT 对分娩时间和出生体重影响的随机对照临床试验（RCT）。检索由两名独立评审员进行，且系统地进行了随机效应荟萃分析。
13 项 RCT 提供了数据，但仅有 5 项试验被认为具有低偏倚风险。8 项研究（61.5%）的结果表明，MPDT 可能降低 PB 和/或 LBW 的发生率。然而，所有荟萃分析的结果均显示 PB [RR：0.88（95% CI：0.72，1.09)]、LBW [RR：0.78（95% CI：0.53，1.17)] 和 PB/LBW [RR：0.52（95% CI：0.08，3.31)]的结果存在差异。
本综述的结果表明，MPDT 并未降低 PB 和/或 LBW 的风险；然而，未来的 RCT 应评估未纳入的特定方面（疾病诊断、范围和严重程度以及 MPDT 的成功率）的影响。
