Pak Jaewoo
Miplant Stems Clinic, 32-3 Chungdam-Dong, Gangnam-Gu, Fourth Floor, Seoul, Korea.
J Med Case Rep. 2011 Jul 7;5:296. doi: 10.1186/1752-1947-5-296.
This is a series of clinical case reports demonstrating that a combination of percutaneously injected autologous adipose-tissue-derived stem cells, hyaluronic acid, platelet rich plasma and calcium chloride may be able to regenerate bones in human osteonecrosis, and with addition of a very low dose of dexamethasone, cartilage in human knee osteoarthritis.
Stem cells were obtained from adipose tissue of abdominal origin by digesting lipoaspirate tissue with collagenase. These stem cells, along with hyaluronic acid, platelet rich plasma and calcium chloride, were injected into the right hip of a 29-year-old Korean woman and a 47-year-old Korean man. They both had a history of right hip osteonecrosis of the femoral head. For cartilage regeneration, a 70-year-old Korean woman and a 79-year-old Korean woman, both with a long history of knee pain due to osteoarthritis, were injected with stem cells along with hyaluronic acid, platelet rich plasma, calcium chloride and a nanogram dose of dexamethasone. Pre-treatment and post-treatment MRI scans, physical therapy, and pain score data were then analyzed.
The MRI data for all the patients in this series showed significant positive changes. Probable bone formation was clear in the patients with osteonecrosis, and cartilage regeneration in the patients with osteoarthritis. Along with MRI evidence, the measured physical therapy outcomes, subjective pain, and functional status all improved. Autologous mesenchymal stem cell injection, in conjunction with hyaluronic acid, platelet rich plasma and calcium chloride, is a promising minimally invasive therapy for osteonecrosis of femoral head and, with low-dose dexamethasone, for osteoarthritis of human knees.
这是一系列临床病例报告,表明经皮注射自体脂肪组织来源的干细胞、透明质酸、富血小板血浆和氯化钙的组合可能能够使人类骨坏死中的骨骼再生,并且添加极低剂量的地塞米松后,能够使人类膝关节骨关节炎中的软骨再生。
通过用胶原酶消化抽脂组织从腹部脂肪组织中获取干细胞。将这些干细胞与透明质酸、富血小板血浆和氯化钙一起注射到一名29岁韩国女性和一名47岁韩国男性的右髋部。他们都有右侧股骨头骨坏死病史。为了进行软骨再生,将干细胞与透明质酸、富血小板血浆、氯化钙和纳克剂量的地塞米松一起注射到两名患有因骨关节炎导致长期膝关节疼痛的韩国女性体内,一名70岁,另一名79岁。然后分析治疗前和治疗后的MRI扫描、物理治疗和疼痛评分数据。
该系列所有患者的MRI数据均显示出显著的积极变化。骨坏死患者中可见明显的可能的骨形成,骨关节炎患者中可见软骨再生。除了MRI证据外,所测量的物理治疗结果、主观疼痛和功能状态均有所改善。自体间充质干细胞注射联合透明质酸、富血小板血浆和氯化钙,对于股骨头骨坏死是一种有前景的微创治疗方法,对于人类膝关节骨关节炎,添加低剂量地塞米松后也是如此。