Lavialle-Guillotreau Virginie, Uro-Coste Emmanuelle, Patelli Annie, Belvèze Patrick, Delisle Marie-Bernadette
Inserm U858, IFR 150, Équipe 15, laboratoire d'anatomie pathologique et d'histologie-cytologie, université Paul-Sabatier Toulouse III, CHU Rangueil, avenue Jean-Poulhès, 31059 Toulouse cedex 9, France.
Ann Pathol. 2011 Jun;31(3):214-7. doi: 10.1016/j.annpat.2011.02.013. Epub 2011 Jun 11.
We report a case of basaloid squamous carcinoma with a spindle cell component of the hypopharynx, in a 61-years-old-man. An excisional biopsy of a pedonculated and polypoid tumour was performed by endoscopy. The histologic examination revealed a biphasic tumour with both a basaloid carcinomatous and a spindle cell component. Focally, osseous metaplasia was seen. The spindle cell component demonstrated immunoreactivity with the p63 epithelial marker. The patient was treated with chemotherapy followed by radiotherapy. The patient has been free of disease for one year. It's the ninth case reported in the literature of a biphasic carcinoma with both a basaloid squamous and a spindle cell component and the first case with osseous metaplasia.
我们报告了一例61岁男性下咽基底样鳞状细胞癌伴梭形细胞成分的病例。通过内镜对一个带蒂息肉样肿瘤进行了切除活检。组织学检查显示为双相肿瘤，具有基底样癌成分和梭形细胞成分。局部可见骨化生。梭形细胞成分对p63上皮标志物呈免疫反应性。患者接受了化疗，随后进行放疗。该患者已无病生存一年。这是文献中报道的第九例同时具有基底样鳞状和梭形细胞成分的双相癌病例，也是首例伴有骨化生的病例。
