DRD3 基因与墨西哥同胞对精神分裂症的关联研究。
Association study of DRD3 gene in schizophrenia in Mexican sib-pairs.
机构信息
Genetics Laboratory, Instituto Nacional de Psiquiatría Ramón de la Fuente, Mexico City, Mexico.
出版信息
Psychiatry Res. 2011 Dec 30;190(2-3):367-8. doi: 10.1016/j.psychres.2011.06.009. Epub 2011 Jul 6.
Abstract
Schizophrenia is a heritable, complex mental disorder. We analysed the DRD3 gene as a candidate to be related to schizophrenia and clinical features in affected sib-pairs. A positive association with the -250A/Ser9 haplotype and a trend toward an association with formal thought disorder were observed. A synergic effect of DRD3 polymorphisms on schizophrenia susceptibility is suggested.
摘要
精神分裂症是一种遗传性的、复杂的精神障碍。我们分析了 DRD3 基因作为与受影响的同卵双生子相关的候选基因，并与临床特征相关。观察到与-250A/Ser9 单倍型呈阳性关联，与形式思维障碍呈关联趋势。提示 DRD3 多态性对精神分裂症易感性有协同作用。
Zotero 插件