脑源性神经营养因子（BDNF）、多巴胺D1受体（DRD1）和多巴胺D3受体（DRD3）基因多态性与精神分裂症患者吸烟行为的相关性
Association of polymorphisms in the BDNF, DRD1 and DRD3 genes with tobacco smoking in schizophrenia.
作者信息
Novak Gabriela, LeBlanc Martha, Zai Clement, Shaikh Sajid, Renou Julien, DeLuca Vincenzo, Bulgin Natalie, Kennedy James L, Le Foll Bernard
机构信息
Neuroscience Research Department, Centre for Addiction and Mental Health, Toronto, Ontario, Canada M5T 1R8.
出版信息
Ann Hum Genet. 2010 Jul;74(4):291-8. doi: 10.1111/j.1469-1809.2010.00578.x. Epub 2010 Apr 25.
Emerging evidence indicates that the DRD1-BDNF-DRD3 cluster plays an important role in nicotine addiction. We have performed an association analysis of 42 SNPs within these genes with cigarette consumption in a group of 341 schizophrenia patients. The ACCG haplotype consisting of four BDNF markers (Val66Met (rs6265), rs11030104, rs2049045 and rs7103411) showed an association with the risk of smoking (p = 0.0002). Both DRD1 markers tested (rs4532 and rs686) and the DRD3 marker (rs1025398) showed association with quantity of tobacco smoked (p = 0.01, 0.005 and 0.002, respectively). Our findings are preliminary; however, they support the involvement of the DRD1, BDNF and DRD3 genes in smoking behaviour.
新出现的证据表明，DRD1 - BDNF - DRD3基因簇在尼古丁成瘾中起重要作用。我们对341名精神分裂症患者群体中这些基因内的42个单核苷酸多态性（SNP）与香烟消费量进行了关联分析。由四个BDNF标记（Val66Met (rs6265)、rs11030104、rs2049045和rs7103411）组成的ACCG单倍型显示与吸烟风险相关（p = 0.0002）。所检测的两个DRD1标记（rs4532和rs686）以及DRD3标记（rs1025398）均显示与吸烟量相关（分别为p = 0.01、0.005和0.002）。我们的发现是初步的；然而，它们支持DRD1、BDNF和DRD3基因参与吸烟行为。
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