左、右侧人结肠癌中 COX-2 与 APC 表达的相关性。

Correlation between COX-2 and APC expression in left versus right-sided human colon cancer.

机构信息

Department of Anatomic Pathology, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, Florida 33612-9497, USA.

出版信息

Anticancer Res. 2011 Jun;31(6):2191-5.

Abstract

BACKGROUND

Because of clinicopathologic and genetic differences between left-sided colorectal cancer (LSCRC) and right-sided colon cancer (RSCC), cyclooxygenase-2(COX-2) and adenomatous polyposis coli (APC) expression may be of clinical relevance.

MATERIALS AND METHODS

Clinicopathologic information for 72 primary colon tumors, 44 left and 28 right, from 72 patients (34 F, 38 M) were analyzed. COX-2 and wild-type APC (W-APC) immunohistochemical expressions were determined for each case. The data were analyzed using the Chi-square test and exact binomial confidence intervals.

RESULTS

Overall, 31 out of 44 (70%) LSCRC were W-COX-2 positive vs. 13 out of 28 (46%) RSCC (p-value=0.042). When evaluated independently of the anatomic location, COX-2 expression showed a borderline statistical correlation with the lack of W-APC protein (p-value=0.054). When considering location of tumors, the inverse correlation between COX-2 and W-APC expression became statistically significant (p-value=0.024).

CONCLUSION

We report a strong inverse correlation between COX-2 and W-APC expression, with COX-2 being more frequently as expressed in LSCRC. These data may be useful to stratify colorectal cancer patients into right- and left-sided and COX-2 expressor and non-expressor subsets, when evaluating COX-2 inhibitor and other targeted therapies in colon cancer.

摘要

背景

由于左半结直肠癌（LSCRC）和右半结肠癌（RSCC）在临床病理和遗传方面存在差异，环氧化酶-2（COX-2）和腺瘤性息肉病基因（APC）的表达可能具有临床相关性。

材料与方法

对 72 例原发性结肠癌患者（34 例女性，38 例男性）的 72 个肿瘤标本（44 个左半结肠癌，28 个右半结肠癌）的临床病理资料进行分析。对每个病例均进行 COX-2 和野生型 APC（W-APC）免疫组化表达分析。采用卡方检验和精确二项式置信区间进行数据分析。

结果

总体而言，44 例 LSCRC 中有 31 例（70%）为 W-COX-2 阳性，28 例 RSCC 中有 13 例（46%）为阳性（p 值=0.042）。当评估 COX-2 表达与 APC 蛋白缺失之间的相关性时，无论解剖位置如何，COX-2 表达均具有统计学相关性（p 值=0.054）。当考虑肿瘤位置时，COX-2 与 W-APC 表达之间的负相关关系具有统计学意义（p 值=0.024）。