Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Jalan Lagoon Selatan, 47500 Bandar Sunway Darul Ehsan, Malaysia.
UniKL MESTECH, A1-1 Jalan TKS1, Taman Kajang Sentral, 43000 Kajang, Malaysia.
Int J Mol Sci. 2019 May 17;20(10):2454. doi: 10.3390/ijms20102454.
Colorectal cancer (CRC) is among the top three cancer with higher incident and mortality rate worldwide. It is estimated that about over than 1.1 million of death and 2.2 million new cases by the year 2030. The current treatment modalities with the usage of chemo drugs such as FOLFOX and FOLFIRI, surgery and radiotherapy, which are usually accompanied with major side effects, are rarely cured along with poor survival rate and at higher recurrence outcome. This trigger the needs of exploring new natural compounds with anti-cancer properties which possess fewer side effects. Curcumin, a common spice used in ancient medicine was found to induce apoptosis by targeting various molecules and signaling pathways involved in CRC. Disruption of the homeostatic balance between cell proliferation and apoptosis could be one of the promoting factors in colorectal cancer progression. In this review, we describe the current knowledge of apoptosis regulation by curcumin in CRC with regard to molecular targets and associated signaling pathways.
结直肠癌（CRC）是全球发病率和死亡率较高的三大癌症之一。据估计，到 2030 年，全球每年将有超过 110 万人死于 CRC，新发病例超过 220 万例。目前的治疗方法包括化疗药物（如 FOLFOX 和 FOLFIRI）、手术和放疗，这些方法通常伴随着严重的副作用，且治愈率低，生存率差，复发率高。这就需要探索具有较少副作用的新型天然化合物的抗癌特性。姜黄素是一种在古代医学中常用的香料，研究发现它通过靶向参与 CRC 的各种分子和信号通路来诱导细胞凋亡。细胞增殖和凋亡之间的动态平衡被破坏可能是 CRC 进展的促进因素之一。在这篇综述中，我们描述了姜黄素对 CRC 中细胞凋亡的调控的最新知识，包括分子靶点和相关信号通路。
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