Kho H G, van Egmond J, Zhuang C F, Zhang G L, Lin G F
Institute for Anaesthesiology, University of Nijmegen, The Netherlands.
Acta Anaesthesiol Scand. 1990 Oct;34(7):563-71. doi: 10.1111/j.1399-6576.1990.tb03146.x.
The patterns of catecholamines (adrenaline and noradrenaline), peptide hormones (adrenocorticotropic hormone, antidiuretic hormone, beta-endorphin, growth hormone and prolactin), hydrocortisone (cortisol) and those of immunoglobulins (IgA, IgG and IgM) and total and differential leucocyte counts in the peripheral blood were investigated during and for 6 days after thyroid surgery in 20 patients (F/M: 18/2) performed under acupuncture anaesthesia, supplemented by small doses of pethidine (mean: 45.0 mg, s.d. 8.9). Throughout surgery the patients remained conscious. During surgery a significant increase in the level of catecholamines and the above-mentioned circulating hormones and a decrease of immunoglobulins were observed, whereas the leucocyte and differential counts demonstrated leucocytosis due to lymphocytosis, a decreased percentage of eosinophils and a remarkably reduced percentage of neutrophils. In the postoperative phase, levels of noradrenaline and beta-endorphin remained elevated, whereas the other circulating hormones gradually returned to normal values. Immunoglobulin levels and eosinophil counts returned to the preinduction values within 24 h, and those of neutrophil and lymphocyte counts within 2 days. Changes in number of monocytes and basophils could not be detected peri- and postoperatively.
对20例（女/男：18/2）接受针刺麻醉并辅以小剂量哌替啶（平均：45.0mg，标准差8.9）进行甲状腺手术的患者，在手术期间及术后6天，研究了外周血中儿茶酚胺（肾上腺素和去甲肾上腺素）、肽类激素（促肾上腺皮质激素、抗利尿激素、β-内啡肽、生长激素和催乳素）、氢化可的松（皮质醇）以及免疫球蛋白（IgA、IgG和IgM）的水平模式，以及白细胞总数和分类计数。在整个手术过程中，患者保持清醒。手术期间观察到儿茶酚胺和上述循环激素水平显著升高，免疫球蛋白水平下降，而白细胞总数和分类计数显示因淋巴细胞增多导致白细胞增多，嗜酸性粒细胞百分比降低，中性粒细胞百分比显著降低。在术后阶段，去甲肾上腺素和β-内啡肽水平仍保持升高，而其他循环激素逐渐恢复至正常水平。免疫球蛋白水平和嗜酸性粒细胞计数在24小时内恢复至诱导前水平，中性粒细胞和淋巴细胞计数在2天内恢复。术前和术后均未检测到单核细胞和嗜碱性粒细胞数量的变化。
