Department of Otorhinolaryngology, Plastic Head and Neck Surgery, Kliniken Maria Hilf Mönchengladbach, 41061 Mönchengladbach, Germany.
Braz J Otorhinolaryngol. 2011 Jun;77(3):373-9. doi: 10.1590/s1808-86942011000300017.
It has been stated, that the administration of Dexamethasone has an impact on the morbidity following tonsillectomy.
To re-calculate the blood values for Dexamethasone when given as fixed doses and to evaluate the effect of Dexamethasone on post-operative nausea, vomiting and bleeding rates following tonsillectomy.
The charts of 272 children (2-15 years) who had undergone tonsillectomy were analyzed. The rates of post-operative nausea, vomiting and bleeding in relation to Dexamethasone were calculated-in general and different doses (0 mg/kg, <0.15 mg/kg, >0.15 mg/kg).
Retrospective cohort study.
Dexamethasone was administered in 121 children (43.7%) according to the preference of the anesthesist (mean dose: 0.2 +/- 0.12 mg/kg; range: 0.04 - 0.62 mg/kg). There was no significant difference in nausea and vomiting (p=0.953) or bleeding (p=0.827) across groups receiving or not receiving Dexamethasone. Stratification into three different groups of Dexamethasone concentration also did not identify a dose-related risk of postoperative nausea or vomiting (p=0.98) or bleeding (p=0.71).
At least under common non-controlled conditions in the clinic, Dexamethasone does not appear to have an effect on nausea or vomiting or bleeding following tonsillectomy.
重新计算固定剂量给予地塞米松时的血药浓度，并评估地塞米松对扁桃体切除术后恶心、呕吐和出血发生率的影响。
分析了 272 例（2-15 岁）行扁桃体切除术患儿的图表。计算了地塞米松与术后恶心、呕吐和出血相关的发生率-总体和不同剂量（0mg/kg、<0.15mg/kg、>0.15mg/kg）。
回顾性队列研究。
根据麻醉师的偏好，121 例患儿（43.7%）给予地塞米松（平均剂量：0.2±0.12mg/kg；范围：0.04-0.62mg/kg）。接受或不接受地塞米松的患儿在恶心和呕吐（p=0.953）或出血（p=0.827）方面无显著差异。分层为地塞米松浓度的三个不同组也未发现术后恶心或呕吐（p=0.98）或出血（p=0.71）与剂量相关的风险。
至少在临床上常见的非对照条件下，地塞米松似乎不会影响扁桃体切除术后的恶心、呕吐或出血。
