Curso de Pós-Graduação em Ciências da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre, Rua Sarmento Leite, 245 Lab.09 Pós-Graduação, Porto Alegre, Rio Grande do Sul, 90050-170, Brazil.
World J Urol. 2011 Aug;29(4):541-6. doi: 10.1007/s00345-011-0724-x. Epub 2011 Jul 8.
To evaluate the influence of age on serum levels of total testosterone (TT), bioavailable testosterone (BT), free testosterone (FT), and sex-hormone binding globulin (SHBG), considering the presence of fasting blood glucose levels and body mass index (BMI) in a selected male population.
A total of 428 men were analyzed. Anthropometry was taken from all, considering BMI as general obesity indicative variable. Fasting blood samples were drawn for determination of plasma glucose levels and serum levels of albumin, TT, and SHBG. The values of BT and FT were calculated from TT, SHBG, and albumin, by Vermeulen's equation. Statistical significance was set at P ≤ 0.05.
Age was negatively correlated to BT (r = -0.301; P < 0.001) and FT (r = -0.273; P < 0.001), but not to TT levels (r = 0.002, P = 0.974). Age was positively correlated to SHBG (r = 0.376; P < 0.001). Age was independently associated with the occurrence of high SHBG levels (OR = 1.07, 95%CI = 1.05-1.10, P < 0.001) and of low BT (OR = 1.04, 95%CI = 1.02-1.07, P < 0.001) and FT levels (OR = 1.05, 95%CI = 1.03-1.08, P < 0.001), but not with low levels of TT (P = 0.08).
Age was significantly associated to high levels of SHBG and to low levels of BT and FT, without significant association to TT. This pattern was independent of BMI and glucose levels.
评估在考虑空腹血糖水平和体重指数（BMI）的情况下，年龄对总睾酮（TT）、生物可利用睾酮（BT）、游离睾酮（FT）和性激素结合球蛋白（SHBG）血清水平的影响，在选定的男性人群中。
共分析了 428 名男性。对所有人进行了人体测量，考虑 BMI 作为一般肥胖的指示变量。抽取空腹血样，用于测定血浆葡萄糖水平和血清白蛋白、TT 和 SHBG 水平。BT 和 FT 的值由 Vermeulen 方程从 TT、SHBG 和白蛋白计算得出。统计学意义设为 P≤0.05。
年龄与 BT（r=-0.301；P<0.001）和 FT（r=-0.273；P<0.001）呈负相关，但与 TT 水平无关（r=0.002，P=0.974）。年龄与 SHBG 呈正相关（r=0.376；P<0.001）。年龄与高 SHBG 水平（OR=1.07，95%CI=1.05-1.10，P<0.001）、低 BT（OR=1.04，95%CI=1.02-1.07，P<0.001）和 FT 水平（OR=1.05，95%CI=1.03-1.08，P<0.001）的发生独立相关，但与 TT 水平无关（P=0.08）。
年龄与 SHBG 水平升高以及 BT 和 FT 水平降低显著相关，与 TT 水平无显著相关性。这种模式独立于 BMI 和血糖水平。
