Division of Host Defense, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Eur J Immunol. 2011 Oct;41(10):2947-54. doi: 10.1002/eji.201141423. Epub 2011 Aug 30.
CD30 ligand (CD30L) plays an important role in the amplification and/or activation of effector CD4(+) T cells, irrespective of Th cell subset. To examine the role of CD30L in allergic rhinitis, we evaluated an OVA model of allergic rhinitis in CD30L knock out (KO) mice on a BALB/c background sensitized with OVA. Symptoms of allergic rhinitis such as eosinophil infiltration into the nasal mucosa were drastically diminished in OVA-sensitized CD30L KO mice following intranasal challenge with OVA. The levels of OVA-specific IgE in the sera and the Th2 response in nasopharynx-associated lymphoid tissues and cervical LNs of CD30L KO mice were significantly lower than those of WT mice following intranasal challenge with OVA. Intranasal administration of CD30-Ig during the effector phase with OVA significantly prevented the development of allergic rhinitis in WT mice. These results suggest that CD30L plays an important role in allergic rhinitis and that the inhibition of CD30L/CD30 signaling might be useful as a novel biological therapy for allergic rhinitis.
CD30 配体（CD30L）在效应性 CD4(+) T 细胞的扩增和/或激活中发挥重要作用，而与 Th 细胞亚群无关。为了研究 CD30L 在变应性鼻炎中的作用，我们在 BALB/c 背景下的 OVA 致敏 CD30L 敲除（KO）小鼠中评估了变应性鼻炎的 OVA 模型。在鼻内挑战 OVA 后，OVA 致敏的 CD30L KO 小鼠的变应性鼻炎症状（如嗜酸性粒细胞浸润鼻黏膜）明显减轻。OVA 鼻内挑战后，CD30L KO 小鼠血清中的 OVA 特异性 IgE 水平和鼻咽相关淋巴组织和颈淋巴结中的 Th2 反应明显低于 WT 小鼠。在 OVA 效应期内给予 CD30-Ig 鼻内给药可显著预防 WT 小鼠变应性鼻炎的发生。这些结果表明 CD30L 在变应性鼻炎中发挥重要作用，抑制 CD30L/CD30 信号可能是治疗变应性鼻炎的一种新的生物疗法。
