Inserm, U954 and Department of Hepato-Gastroenterology, University Hospital of Nancy, Vandoeuvre-Les-Nancy, France.
Inflamm Bowel Dis. 2012 Apr;18(4):697-702. doi: 10.1002/ibd.21777. Epub 2011 Jul 7.
Cystitis is the most common genitourinary complication in Crohn's disease (CD). We assessed the prevalence of and risk factors for urinary tract infections (UTI) in inflammatory bowel diseases (IBD).
Among the 1173 IBD patients of the "Nancy IBD cohort" seen between January 1, 2000 and December 31, 2009, 56 hospitalized patients had 76 documented UTI. Prevalence of UTI in IBD was calculated using rates of UTI among non-IBD patients hospitalized during the same period. The cases were compared to 175 matched IBD patients without UTI hospitalized during the same period to identify risk factors for UTI.
Prevalence of UTI was 4% in IBD patients versus 3.3% in non-IBD patients (P = 0.1). Prevalence of UTI was 4.5% and 2.1% in ulcerative colitis (UC) and CD patients, respectively (P = 0.6). Risk factors for UTI in CD patients were perianal disease (odds ratio [OR] = 2.28, 95% confidence interval [CI], 1.06-4.89; P = 0.04) and colonic disease (OR = 2.42, 95% CI, 1.05-5.58; P = 0.04). Male gender (OR = 0.38, 95% CI, 0.17-0.85, P = 0.02) and noncomplicated behavior (OR = 0.26, 95% CI, 0.11-0.60, P = 0.002) were protective factors against UTI in CD. In UC patients, age over 40 years (OR = 9.59, 95% CI, 1.93-47.74; P = 0.006) and disease duration over 11 months (OR = 10.77, 95% CI, 1.68-68.89, P = 0.01) were risk factors for UTI. Male gender was negatively associated with UTI (OR = 0.04, 95% CI, 0.01-0.36, P = 0.00006).
Hospitalized IBD patients are not at increased risk of UTI. Risk factors for UTI include perianal disease and colonic disease in CD and age and longer disease duration in UC.
膀胱炎是克罗恩病（CD）最常见的泌尿生殖系统并发症。我们评估了炎症性肠病（IBD）患者尿路感染（UTI）的患病率和危险因素。
在 2000 年 1 月 1 日至 2009 年 12 月 31 日期间，“南希 IBD 队列”中的 1173 名 IBD 患者中，56 名住院患者有 76 例有记录的 UTI。使用同期住院的非 IBD 患者中 UTI 的发生率计算 IBD 患者中 UTI 的患病率。将这些病例与同期住院的 175 例无 UTI 的匹配 IBD 患者进行比较，以确定 UTI 的危险因素。
IBD 患者的 UTI 患病率为 4%，而非 IBD 患者为 3.3%（P=0.1）。溃疡性结肠炎（UC）和 CD 患者的 UTI 患病率分别为 4.5%和 2.1%（P=0.6）。CD 患者 UTI 的危险因素包括肛周疾病（比值比[OR]=2.28，95%置信区间[CI]，1.06-4.89；P=0.04）和结肠疾病（OR=2.42，95%CI，1.05-5.58；P=0.04）。男性（OR=0.38，95%CI，0.17-0.85，P=0.02）和非复杂性行为（OR=0.26，95%CI，0.11-0.60，P=0.002）是 CD 患者 UTI 的保护因素。在 UC 患者中，年龄大于 40 岁（OR=9.59，95%CI，1.93-47.74；P=0.006）和疾病持续时间超过 11 个月（OR=10.77，95%CI，1.68-68.89，P=0.01）是 UTI 的危险因素。男性与 UTI 呈负相关（OR=0.04，95%CI，0.01-0.36，P=0.00006）。
住院 IBD 患者发生 UTI 的风险并未增加。UTI 的危险因素包括 CD 中的肛周疾病和结肠疾病，以及 UC 中的年龄和较长的疾病持续时间。
