Tancredi V, Zona C, Velotti F, Eusebi F, Santoni A
Dipartimento Medicina Sperimentale e Scienze Biochimiche, Università di Roma Tor Vergata, Italy.
Brain Res. 1990 Aug 13;525(1):149-51. doi: 10.1016/0006-8993(90)91331-a.
The effects of recombinant interleukin-2 (rIL-2) on the potentiation of the synaptic transmission were studied in rat hippocampal slices by using extracellular field potential recordings. The application of rIL-2 inhibited the induction of both short-term (STP) and long-term potentiation (LTP) in a dose-dependent manner. In addition, rIL-2 (1000 U/ml) reduced both post-tetanic potentiation (PTP) and LTP maintenance phase. The possible involvement of rIL-2 action on the synaptic potentiation with the enzymatic activity of protein kinase systems is discussed.
通过细胞外场电位记录，研究了重组白细胞介素-2（rIL-2）对大鼠海马切片中突触传递增强的影响。rIL-2的应用以剂量依赖性方式抑制了短期（STP）和长期增强（LTP）的诱导。此外，rIL-2（1000 U/ml）降低了强直后增强（PTP）和LTP维持阶段。讨论了rIL-2作用对突触增强与蛋白激酶系统酶活性之间可能的关联。
