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表皮生长因子可增强大鼠海马脑片的短期突触增强，并促进长期突触增强的诱导。

Epidermal growth factor enhances short-term potentiation and facilitates induction of long-term potentiation in rat hippocampal slices.

作者信息

Abe K, Xie F J, Saito H

机构信息

Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.

出版信息

Brain Res. 1991 Apr 26;547(1):171-4. doi: 10.1016/0006-8993(91)90589-n.

DOI:10.1016/0006-8993(91)90589-n
PMID:1860069
Abstract

Effects of recombinant human epidermal growth factor (hEGF) on short-term potentiation (STP) of evoked potential were investigated in Schaffer/commissural-CA1 pyramidal cell synapses of rat hippocampal slices. Perfusion of hEGF (6-60 ng/ml) significantly enhanced the STP induced by shorter tetanus (11 impulses at 100 Hz) in a concentration-dependent manner and the effect resulted in generation of long-term potentiation (LTP). The results suggest that hEGF can activate the mechanisms related to induction of LTP.

摘要

在大鼠海马脑片的Schaffer/联合-CA1锥体细胞突触中，研究了重组人表皮生长因子（hEGF）对诱发电位短期增强（STP）的影响。灌注hEGF（6 - 60 ng/ml）以浓度依赖的方式显著增强了由较短强直刺激（100 Hz下11个脉冲）诱导的STP，并且该效应导致了长时程增强（LTP）的产生。结果表明，hEGF可以激活与LTP诱导相关的机制。

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