The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Nat Immunol. 2011 Jun;12(6):472-7. doi: 10.1038/ni.2019.
Humoral immunity requires interaction between specialized populations of B cells and CD4(+) T cells, called follicular helper T cells (T(FH) cells), in the germinal center (GC) to produce memory B cells and long-lived plasma cells. Molecular crosstalk between GC B cells and T(FH) cells influences the survival, proliferation and differentiation of each cell type. This pairing of GC B cells and T(FH) cells also occurs at the transcriptional level as the Bcl-6–IRF4–Blimp-1 axis, which is crucial for B cell differentiation, is also essential for the T(FH) cell identity. Less is known about the memory B cells that arise from the GC pool, as they seem to be distinctly 'programmed' on the basis of their antigen receptor affinity to enter the long-lived memory pool.
体液免疫需要专门的 B 细胞和 CD4(+)T 细胞群体（称为滤泡辅助 T 细胞（T(FH) 细胞））之间相互作用，在生发中心（GC）中产生记忆 B 细胞和长寿命浆细胞。GC B 细胞和 T(FH) 细胞之间的分子串扰影响每种细胞类型的存活、增殖和分化。这种 GC B 细胞和 T(FH) 细胞的配对也发生在转录水平上，因为 Bcl-6-IRF4-Blimp-1 轴对于 B 细胞分化至关重要，对于 T(FH) 细胞的特性也至关重要。关于从 GC 池中产生的记忆 B 细胞知之甚少，因为它们似乎根据其抗原受体亲和力而被明显“编程”，以进入长寿命的记忆池。
