Damjancic P, Vierhapper H
Division of Clinical Endocrinology and Diabetology, University of Vienna, Austria.
Exp Clin Endocrinol. 1990 Aug;95(3):315-21. doi: 10.1055/s-0029-1210971.
To study the potential impact of glucocorticoids on the effects of human atrial natriuretic peptide (hANP) in man, the diuretic and natriuretic response to intravenous bolus doses of hANP (50 and 100 micrograms) was studied in seven male patients with deficient endogenous glucocorticoid synthesis, both during withdrawal of glucocorticoid therapy and during subsequent substitution with dexamethasone. Plasma concentrations of ACTH, though markedly suppressed by dexamethasone as compared to the unsubstituted state were not influenced by exogenous hANP either during deprival or substitution of glucocorticoids. Basal plasma concentrations of hANP were 10.3 +/- 8.4 pmol/l and 19.3 +/- 11.1 pmol/l during glucocorticoid withdrawal and following substitution with dexamethasone, respectively. When substituted with glucocorticoids, patients responded to hANP (100 micrograms) with an increase (p less than 0.025) in diuresis and sodium excretion, whereas no changes in diuresis and sodium excretion were seen following intravenous hANP during glucocorticoid withdrawal. These results suggest that glucocorticoids may have a permissive effect on hANP-mediated natriuresis and diuresis.
为研究糖皮质激素对人体内源性心房利钠肽（hANP）作用的潜在影响，我们对7例内源性糖皮质激素合成不足的男性患者进行了研究，观察他们在停用糖皮质激素治疗期间以及随后用地塞米松替代治疗期间，静脉推注不同剂量hANP（50微克和100微克）后的利尿和利钠反应。促肾上腺皮质激素（ACTH）的血浆浓度，与未替代状态相比，在地塞米松治疗时显著降低，但在糖皮质激素剥夺或替代期间，外源性hANP均未对其产生影响。在停用糖皮质激素期间和用地塞米松替代治疗后，hANP的基础血浆浓度分别为10.3±8.4 pmol/l和19.3±11.1 pmol/l。当用糖皮质激素替代治疗时，患者对hANP（100微克）产生反应，利尿和钠排泄增加（p＜0.025），而在停用糖皮质激素期间静脉注射hANP后，利尿和钠排泄未见变化。这些结果表明，糖皮质激素可能对hANP介导的利钠和利尿作用具有允许作用。
