黑腹果蝇FB-NOF转座元件的特征分析
Characterization of the FB-NOF transposable element of Drosophila melanogaster.
作者信息
Harden N, Ashburner M
机构信息
Department of Genetics, University of Cambridge, England.
出版信息
Genetics. 1990 Oct;126(2):387-400. doi: 10.1093/genetics/126.2.387.
Abstract
FB-NOF is a composite transposable element of Drosophila melanogaster. It is composed of foldback sequences, of variable length, which flank a 4-kb NOF sequence with 308-bp inverted repeat termini. The NOF sequence could potentially code for a 120-kD polypeptide. The FB-NOF element is responsible for unstable mutations of the white gene (wc and wDZL) and is associated with the large TEs of G. Ising. Although most strains of D. melanogaster have 20-30 sites of FB insertion, FB-NOF elements are usually rare, many strains lack this composite element or have only one copy of it. A few strains, including wDZL and Basc have many (8-21) copies of FB-NOF, and these show a tendency to insert at "hot-spots." These strains also have an increased number of FB elements. The DNA sequence of the NOF region associated with TE146(Z) has been determined.
摘要
FB - NOF是黑腹果蝇的一种复合转座元件。它由长度可变的回文序列组成，这些回文序列位于一个4kb的NOF序列两侧，该序列具有308bp的反向重复末端。NOF序列可能编码一种120kD的多肽。FB - NOF元件导致白色基因的不稳定突变（wc和wDZL），并且与伊辛氏果蝇的大型转座元件相关。尽管大多数黑腹果蝇品系有20 - 30个FB插入位点，但FB - NOF元件通常很罕见，许多品系缺乏这种复合元件或仅有一个拷贝。少数品系，包括wDZL和Basc，有许多（8 - 21）个FB - NOF拷贝，并且这些拷贝倾向于插入到“热点”。这些品系的FB元件数量也有所增加。与TE146(Z)相关的NOF区域的DNA序列已被确定。
相似文献
1
Characterization of the FB-NOF transposable element of Drosophila melanogaster.黑腹果蝇FB-NOF转座元件的特征分析
Genetics. 1990 Oct;126(2):387-400. doi: 10.1093/genetics/126.2.387.
2
FB-NOF is a non-autonomous transposable element, expressed in Drosophila melanogaster and present only in the melanogaster group.FB-NOF 是一个非自主转座元件，在果蝇中表达，仅存在于果蝇组中。
Gene. 2013 Sep 10;526(2):459-63. doi: 10.1016/j.gene.2013.04.082. Epub 2013 May 15.
3
FB elements are the common basis for the instability of the wDZL and wC Drosophila mutations.FB元件是wDZL和wDrosophila突变不稳定的共同基础。
Cell. 1982 Sep;30(2):551-65. doi: 10.1016/0092-8674(82)90252-5.
4
Molecular and bioinformatic analysis of the FB-NOF transposable element.FB-NOF转座元件的分子与生物信息学分析
Gene. 2006 Apr 12;371(1):130-5. doi: 10.1016/j.gene.2005.11.020. Epub 2006 Feb 14.
5
Distinct characteristics of loop sequences of two Drosophila foldback transposable elements.两种果蝇折回转座元件环序列的独特特征。
Nucleic Acids Res. 1985 Jan 25;13(2):485-500. doi: 10.1093/nar/13.2.485.
6
Unusual structure of the FB family of transposable elements in Drosophila.果蝇中转座元件FB家族的异常结构。
Cell. 1981 Jun;24(3):753-63. doi: 10.1016/0092-8674(81)90101-x.
7
The molecular structure of TE146 and its derivatives in Drosophila melanogaster.果蝇中TE146及其衍生物的分子结构。
Genetics. 1991 Jun;128(2):357-72. doi: 10.1093/genetics/128.2.357.
8
The pogo transposable element family of Drosophila melanogaster.黑腹果蝇的Pogo转座因子家族。
Mol Gen Genet. 1992 Mar;232(1):126-34. doi: 10.1007/BF00299145.
9
Spontaneous excision of a large composite transposable element of Drosophila melanogaster.黑腹果蝇一个大型复合转座元件的自发切除。
Nature. 1985;316(6023):81-3. doi: 10.1038/316081a0.
10
Complete foldback transposable elements encode a novel protein found in Drosophila melanogaster.完整的回文转座元件编码一种在黑腹果蝇中发现的新型蛋白质。
EMBO J. 1989 Jun;8(6):1887-94. doi: 10.1002/j.1460-2075.1989.tb03585.x.
引用本文的文献
1
The Foldback-like element Galileo belongs to the P superfamily of DNA transposons and is widespread within the Drosophila genus.类回文元件伽利略属于DNA转座子的P超家族，在果蝇属中广泛存在。
Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):2957-62. doi: 10.1073/pnas.0712110105. Epub 2008 Feb 19.
2
Recurrent insertion and duplication generate networks of transposable element sequences in the Drosophila melanogaster genome.反复插入和复制在黑腹果蝇基因组中产生了转座元件序列网络。
Genome Biol. 2006;7(11):R112. doi: 10.1186/gb-2006-7-11-r112.
3
An FB-NOF mediated duplication of the white gene is responsible for the zeste1 phenotype in some Drosophila melanogaster unstable strains.在一些黑腹果蝇不稳定品系中，FB-NOF介导的白色基因重复导致了zeste1表型。
Mol Genet Genomics. 2006 Jan;275(1):35-43. doi: 10.1007/s00438-005-0068-6. Epub 2005 Dec 7.
4
Molecular characterization and chromosomal distribution of Galileo, Kepler and Newton, three foldback transposable elements of the Drosophila buzzatii species complex.果蝇巴氏种复合体的三种回文转座元件伽利略、开普勒和牛顿的分子特征及染色体分布
Genetics. 2005 Apr;169(4):2047-59. doi: 10.1534/genetics.104.035048. Epub 2005 Feb 3.
5
FB elements can promote exon shuffling: a promoter-less white allele can be reactivated by FB mediated transposition in Drosophila melanogaster.FB元件可促进外显子改组：在黑腹果蝇中，一个无启动子的白色等位基因可通过FB介导的转座作用而重新激活。
Mol Genet Genomics. 2004 May;271(4):394-401. doi: 10.1007/s00438-004-1007-7. Epub 2004 Apr 2.
6
The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective.黑腹果蝇常染色质中的转座元件：基因组学视角
Genome Biol. 2002;3(12):RESEARCH0084. doi: 10.1186/gb-2002-3-12-research0084. Epub 2002 Dec 23.
7
FARE, a new family of foldback transposons in Arabidopsis.FARE，拟南芥中一个新的回文转座子家族。
Genetics. 2000 Dec;156(4):1983-95. doi: 10.1093/genetics/156.4.1983.
8
Construction and transposition of a 100-kilobase extended P element in Drosophila.果蝇中一个100千碱基扩展P因子的构建与转座
Genome Res. 2000 Oct;10(10):1605-16. doi: 10.1101/gr.151700.
9
Foldback transposable elements in plants.植物中的回文转座元件。
Plant Mol Biol. 1997 Jul;34(5):831-5. doi: 10.1023/a:1005855008823.
10
Genetic and molecular analysis of a set of unstable white mutants in Drosophila melanogaster.黑腹果蝇一组不稳定白色突变体的遗传与分子分析
Genetica. 1996 Oct;98(2):179-92. doi: 10.1007/BF00121365.
本文引用的文献
1
The Regulation of White Locus Expression: A Dominant Mutant Allele at the White Locus of DROSOPHILA MELANOGASTER.白眼基因表达的调控：果蝇白眼基因座的显性突变等位基因。
Genetics. 1980 Jun;95(2):341-53. doi: 10.1093/genetics/95.2.341.
2
Interactions between WHITE Genes Carried by a Large Transposing Element and the ZESTE Allele in DROSOPHILA MELANOGASTER.转座因子携带的 WHITE 基因与果蝇 ZESTE 等位基因的相互作用。
Genetics. 1986 Mar;112(3):551-75. doi: 10.1093/genetics/112.3.551.
3
Molecular analysis of large transposable elements carrying the white locus of Drosophila melanogaster.大转座子携带的果蝇黑素体的白色基因座的分子分析。
EMBO J. 1983;2(6):853-60. doi: 10.1002/j.1460-2075.1983.tb01513.x.
4
Molecular cloning of the white locus region of Drosophila melanogaster using a large transposable element.利用一个大的可转座元件对黑腹果蝇的白区位点区域进行分子克隆。
EMBO J. 1982;1(1):93-8. doi: 10.1002/j.1460-2075.1982.tb01130.x.
5
A comprehensive set of sequence analysis programs for the VAX.一套适用于VAX的综合序列分析程序。
Nucleic Acids Res. 1984 Jan 11;12(1 Pt 1):387-95. doi: 10.1093/nar/12.1part1.387.
6
Graphic methods to determine the function of nucleic acid sequences.用于确定核酸序列功能的图解方法。
Nucleic Acids Res. 1984 Jan 11;12(1 Pt 2):521-38. doi: 10.1093/nar/12.1part2.521.
7
Structure of chromosomal rearrangements induced by the FB transposable element in Drosophila.果蝇中FB转座元件诱导的染色体重排结构
Nature. 1984;308(5957):323-7. doi: 10.1038/308323a0.
8
High-frequency precise excision of the Drosophila foldback transposable element.果蝇回文转座元件的高频精确切除
Nature. 1983;303(5914):259-60. doi: 10.1038/303259a0.
9
FB elements are the common basis for the instability of the wDZL and wC Drosophila mutations.FB元件是wDZL和wDrosophila突变不稳定的共同基础。
Cell. 1982 Sep;30(2):551-65. doi: 10.1016/0092-8674(82)90252-5.
10
The unstable wDZL mutation of Drosophila is caused by a 13 kilobase insertion that is imprecisely excised in phenotypic revertants.果蝇不稳定的wDZL突变是由一个13千碱基的插入片段引起的，该插入片段在表型回复体中被不准确地切除。
Cell. 1982 Sep;30(2):543-50. doi: 10.1016/0092-8674(82)90251-3.
Zotero 插件