Suppr超能文献

黑腹果蝇FB-NOF转座元件的特征分析

Characterization of the FB-NOF transposable element of Drosophila melanogaster.

作者信息

Harden N, Ashburner M

机构信息

Department of Genetics, University of Cambridge, England.

出版信息

Genetics. 1990 Oct;126(2):387-400. doi: 10.1093/genetics/126.2.387.

DOI:10.1093/genetics/126.2.387
PMID:2174013
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1204193/
Abstract

FB-NOF is a composite transposable element of Drosophila melanogaster. It is composed of foldback sequences, of variable length, which flank a 4-kb NOF sequence with 308-bp inverted repeat termini. The NOF sequence could potentially code for a 120-kD polypeptide. The FB-NOF element is responsible for unstable mutations of the white gene (wc and wDZL) and is associated with the large TEs of G. Ising. Although most strains of D. melanogaster have 20-30 sites of FB insertion, FB-NOF elements are usually rare, many strains lack this composite element or have only one copy of it. A few strains, including wDZL and Basc have many (8-21) copies of FB-NOF, and these show a tendency to insert at "hot-spots." These strains also have an increased number of FB elements. The DNA sequence of the NOF region associated with TE146(Z) has been determined.

摘要

FB - NOF是黑腹果蝇的一种复合转座元件。它由长度可变的回文序列组成，这些回文序列位于一个4kb的NOF序列两侧，该序列具有308bp的反向重复末端。NOF序列可能编码一种120kD的多肽。FB - NOF元件导致白色基因的不稳定突变（wc和wDZL），并且与伊辛氏果蝇的大型转座元件相关。尽管大多数黑腹果蝇品系有20 - 30个FB插入位点，但FB - NOF元件通常很罕见，许多品系缺乏这种复合元件或仅有一个拷贝。少数品系，包括wDZL和Basc，有许多（8 - 21）个FB - NOF拷贝，并且这些拷贝倾向于插入到“热点”。这些品系的FB元件数量也有所增加。与TE146(Z)相关的NOF区域的DNA序列已被确定。

相似文献

1
Characterization of the FB-NOF transposable element of Drosophila melanogaster.
Genetics. 1990 Oct;126(2):387-400. doi: 10.1093/genetics/126.2.387.
2
FB-NOF is a non-autonomous transposable element, expressed in Drosophila melanogaster and present only in the melanogaster group.
Gene. 2013 Sep 10;526(2):459-63. doi: 10.1016/j.gene.2013.04.082. Epub 2013 May 15.
3
FB elements are the common basis for the instability of the wDZL and wC Drosophila mutations.
Cell. 1982 Sep;30(2):551-65. doi: 10.1016/0092-8674(82)90252-5.
4
Molecular and bioinformatic analysis of the FB-NOF transposable element.
Gene. 2006 Apr 12;371(1):130-5. doi: 10.1016/j.gene.2005.11.020. Epub 2006 Feb 14.
5
Distinct characteristics of loop sequences of two Drosophila foldback transposable elements.
Nucleic Acids Res. 1985 Jan 25;13(2):485-500. doi: 10.1093/nar/13.2.485.
6
Unusual structure of the FB family of transposable elements in Drosophila.
Cell. 1981 Jun;24(3):753-63. doi: 10.1016/0092-8674(81)90101-x.
7
The molecular structure of TE146 and its derivatives in Drosophila melanogaster.
Genetics. 1991 Jun;128(2):357-72. doi: 10.1093/genetics/128.2.357.
8
The pogo transposable element family of Drosophila melanogaster.
Mol Gen Genet. 1992 Mar;232(1):126-34. doi: 10.1007/BF00299145.
9
Spontaneous excision of a large composite transposable element of Drosophila melanogaster.
Nature. 1985;316(6023):81-3. doi: 10.1038/316081a0.
10
Complete foldback transposable elements encode a novel protein found in Drosophila melanogaster.
EMBO J. 1989 Jun;8(6):1887-94. doi: 10.1002/j.1460-2075.1989.tb03585.x.

引用本文的文献

1
The Foldback-like element Galileo belongs to the P superfamily of DNA transposons and is widespread within the Drosophila genus.
Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):2957-62. doi: 10.1073/pnas.0712110105. Epub 2008 Feb 19.
2
Recurrent insertion and duplication generate networks of transposable element sequences in the Drosophila melanogaster genome.
Genome Biol. 2006;7(11):R112. doi: 10.1186/gb-2006-7-11-r112.
3
An FB-NOF mediated duplication of the white gene is responsible for the zeste1 phenotype in some Drosophila melanogaster unstable strains.
Mol Genet Genomics. 2006 Jan;275(1):35-43. doi: 10.1007/s00438-005-0068-6. Epub 2005 Dec 7.
4
Molecular characterization and chromosomal distribution of Galileo, Kepler and Newton, three foldback transposable elements of the Drosophila buzzatii species complex.
Genetics. 2005 Apr;169(4):2047-59. doi: 10.1534/genetics.104.035048. Epub 2005 Feb 3.
5
FB elements can promote exon shuffling: a promoter-less white allele can be reactivated by FB mediated transposition in Drosophila melanogaster.
Mol Genet Genomics. 2004 May;271(4):394-401. doi: 10.1007/s00438-004-1007-7. Epub 2004 Apr 2.
6
The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective.
Genome Biol. 2002;3(12):RESEARCH0084. doi: 10.1186/gb-2002-3-12-research0084. Epub 2002 Dec 23.
7
FARE, a new family of foldback transposons in Arabidopsis.
Genetics. 2000 Dec;156(4):1983-95. doi: 10.1093/genetics/156.4.1983.
8
Construction and transposition of a 100-kilobase extended P element in Drosophila.
Genome Res. 2000 Oct;10(10):1605-16. doi: 10.1101/gr.151700.
9
Foldback transposable elements in plants.
Plant Mol Biol. 1997 Jul;34(5):831-5. doi: 10.1023/a:1005855008823.
10
Genetic and molecular analysis of a set of unstable white mutants in Drosophila melanogaster.
Genetica. 1996 Oct;98(2):179-92. doi: 10.1007/BF00121365.

本文引用的文献

1
The Regulation of White Locus Expression: A Dominant Mutant Allele at the White Locus of DROSOPHILA MELANOGASTER.
Genetics. 1980 Jun;95(2):341-53. doi: 10.1093/genetics/95.2.341.
2
Interactions between WHITE Genes Carried by a Large Transposing Element and the ZESTE Allele in DROSOPHILA MELANOGASTER.
Genetics. 1986 Mar;112(3):551-75. doi: 10.1093/genetics/112.3.551.
3
Molecular analysis of large transposable elements carrying the white locus of Drosophila melanogaster.
EMBO J. 1983;2(6):853-60. doi: 10.1002/j.1460-2075.1983.tb01513.x.
4
Molecular cloning of the white locus region of Drosophila melanogaster using a large transposable element.
EMBO J. 1982;1(1):93-8. doi: 10.1002/j.1460-2075.1982.tb01130.x.
5
A comprehensive set of sequence analysis programs for the VAX.
Nucleic Acids Res. 1984 Jan 11;12(1 Pt 1):387-95. doi: 10.1093/nar/12.1part1.387.
6
Graphic methods to determine the function of nucleic acid sequences.
Nucleic Acids Res. 1984 Jan 11;12(1 Pt 2):521-38. doi: 10.1093/nar/12.1part2.521.
7
Structure of chromosomal rearrangements induced by the FB transposable element in Drosophila.
Nature. 1984;308(5957):323-7. doi: 10.1038/308323a0.
8
High-frequency precise excision of the Drosophila foldback transposable element.
Nature. 1983;303(5914):259-60. doi: 10.1038/303259a0.
9
FB elements are the common basis for the instability of the wDZL and wC Drosophila mutations.
Cell. 1982 Sep;30(2):551-65. doi: 10.1016/0092-8674(82)90252-5.
10
The unstable wDZL mutation of Drosophila is caused by a 13 kilobase insertion that is imprecisely excised in phenotypic revertants.
Cell. 1982 Sep;30(2):543-50. doi: 10.1016/0092-8674(82)90251-3.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验