用于确定核酸序列功能的图解方法。
Graphic methods to determine the function of nucleic acid sequences.
作者信息
Staden R
出版信息
Nucleic Acids Res. 1984 Jan 11;12(1 Pt 2):521-38. doi: 10.1093/nar/12.1part2.521.
Abstract
We describe an interactive computer program (ANALYSEQ) that is used from a simple graphics terminal. The main purpose of the program is to determine the function of nucleic acid sequences but it also offers the simpler listing, searching and counting options. It contains methods to locate genes by looking for the effects that coding for a protein has on the coding sequence, to locate tRNA genes by looking for secondary structure and conserved bases, and methods to locate signals such as promoters. Techniques to identify unusual regions of sequence and to search for potential Z DNA-forming regions are also included. Most of the routines produce graphical output which gives ease of interpretation and allows superposition of several independent forms of analysis.
摘要
我们描述了一个可从简单图形终端使用的交互式计算机程序（ANALYSEQ）。该程序的主要目的是确定核酸序列的功能，但它也提供了更简单的列表、搜索和计数选项。它包含通过寻找蛋白质编码对编码序列的影响来定位基因的方法，通过寻找二级结构和保守碱基来定位tRNA基因的方法，以及定位启动子等信号的方法。还包括识别序列异常区域和搜索潜在Z-DNA形成区域的技术。大多数程序会生成图形输出，便于解释，并允许叠加几种独立的分析形式。
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