School of Physics and Chemistry, Xihua University, Chengdu 610039, P.R. China.
Nat Prod Res. 2011 Jul;25(12):1150-60. doi: 10.1080/14786419.2010.495070.
Excessive accumulation of iron in the body can lead to organ injury. Some flavonoids which possess high affinity to iron can be used as iron chelators for curing iron overload diseases such as haemochromatosis. In this article, the effects of baicalin and quercetin on different mouse tissues (liver, kidney and heart) afflicted with iron overload-induced injury were studied. It was found that after administration of 500 mg kg⁻¹ iron dextran for 45 days, the degree of oxidative injury in the three organs was different. When iron dextran-induced iron-overloaded mice were fed a diet containing baicalin or quercetin (1% w/w), both flavonoids showed significant effects in suppressing iron overload-induced injury. The efficiencies of both flavonoids on different tissues varied. Both flavonoids caused a significant decrease of iron content in liver and kidney tissues but not in the heart, whereas the flavonoids were more efficient in inhibiting the increase of carbonyl content and the thiobarbituric acid reactive substance levels in heart tissues. The results indicate that the protective effects of baicalin and quercetin on different tissues of iron-overloaded mice are different.
体内铁元素的过度积累可能导致器官损伤。一些具有高亲和力的类黄酮可以作为铁螯合剂，用于治疗铁过载疾病，如血色素沉着症。本文研究了黄芩苷和槲皮素对铁过载引起的损伤的不同小鼠组织（肝、肾和心脏）的影响。结果发现，给予 500mgkg-1 右旋糖酐铁 45 天后，三个器官的氧化损伤程度不同。当铁过载诱导的铁过载小鼠喂食含有黄芩苷或槲皮素（1%w/w）的饮食时，两种黄酮类化合物均表现出显著抑制铁过载诱导损伤的作用。两种黄酮类化合物对不同组织的效果不同。两种黄酮类化合物均能显著降低肝、肾组织中铁含量，但对心脏组织中铁含量无影响，而黄酮类化合物在抑制心脏组织羰基含量和硫代巴比妥酸反应物质水平升高方面更为有效。结果表明，黄芩苷和槲皮素对铁过载小鼠不同组织的保护作用不同。
