Department of Medicine, Division of Hematology/Oncology, University of Miami Miller School of Medicine, Sylvester Comprehensive Cancer Center, Miami, FL 33136, USA.
Leuk Lymphoma. 2011 Dec;52(12):2254-61. doi: 10.3109/10428194.2011.603443. Epub 2011 Aug 24.
The incidence of patients with multiple primary tumors has been increasing in recent years. The association between non-Hodgkin lymphomas (NHL) and renal cell carcinoma (RCC) is unclear. The presentation of 10 patients with co-existent NHL and RCC at our institution in the past 3 years led us to explore whether this was a chance association or a statistically significant phenomenon. We used the US Surveillance, Epidemiology and End Results (SEER) program (www.seer.cancer.gov) from 1973 to 2006 to identify a total of 892 445 537 subjects aged 18-84, with known values for race and gender at risk for NHL and RCC. Among these, 181 009 were diagnosed with NHL, 118 122 were diagnosed with RCC and 1039 had both NHL and RCC. This was significantly higher than the expected number of 24 with co-existent NHL and RCC (p < 0.0001). The observed number (O) of RCC after NHL was significantly higher than the expected number (E) (O/E: 1.51; 95% confidence interval [CI] 1.36-1.66), with the O/E ratio remaining elevated across the various follow-up time intervals. The observed number of NHL after RCC was not significantly different from the expected number (O/E: 1.09; 95% CI 0.98-1.22). In univariate analyses, race and gender were significantly associated with an increased cumulative incidence of RCC after NHL. Multivariate analysis with age, race and gender revealed that white males had a higher cumulative incidence of RCC after NHL. These findings suggest that patients with NHL are at increased risk for RCC.
近年来，多发性肿瘤患者的发病率一直在上升。非霍奇金淋巴瘤（NHL）与肾细胞癌（RCC）之间的关联尚不清楚。在过去 3 年中，我们机构收治了 10 例同时患有 NHL 和 RCC 的患者，这促使我们探讨这种情况是偶然关联还是具有统计学意义的现象。我们使用了美国监测、流行病学和最终结果（SEER）计划（www.seer.cancer.gov），该计划涵盖了 1973 年至 2006 年的 892 445 537 名年龄在 18-84 岁之间的个体，这些个体的种族和性别风险因素已知，且患有 NHL 和 RCC。在这些个体中，有 181 009 人被诊断患有 NHL，118 122 人被诊断患有 RCC，1039 人同时患有 NHL 和 RCC。这显著高于同时患有 NHL 和 RCC 的预期人数（24 人）（p < 0.0001）。患有 NHL 后的 RCC 实际观察到的数量（O）显著高于预期数量（E）（O/E：1.51；95%置信区间[CI] 1.36-1.66），并且在各种随访时间间隔内，O/E 比值均保持升高。患有 RCC 后的 NHL 实际观察到的数量与预期数量无显著差异（O/E：1.09；95% CI 0.98-1.22）。在单变量分析中，种族和性别与 NHL 后 RCC 的累积发病率增加显著相关。在多变量分析中，将年龄、种族和性别纳入分析后，结果表明，白人男性患有 NHL 后 RCC 的累积发病率更高。这些发现表明，患有 NHL 的患者发生 RCC 的风险增加。
