Rabbani F, Russo P
Urology Service, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
Urology. 1999 Jul;54(1):28-33. doi: 10.1016/s0090-4295(99)00066-7.
To determine the incidence of non-Hodgkin's lymphoma (NHL) and renal cell carcinoma (RCC) after a diagnosis of the other malignancy.
The 1973 to 1994 Surveillance, Epidemiology, and End Results (SEER) data base was used to determine the age-, sex-, race-, and calendar year-specific incidence rates for each year for RCC and NHL. The expected number of second cancers for each sex, race, and follow-up period (less than 1, 1 to 5, 5 to 10, and 10 or more years) was obtained by multiplying these incidence rates by the age-, sex-, race-, and calendar year-specific number of person-years at risk, with these products summed over the different age groups and calendar years. The standardized incidence ratio (SIR) was calculated (observed/expected number of second cancers), with statistical significance determined using the Poisson test.
From 1973 to 1994, 32,293 individuals in the SEER data base were diagnosed with RCC and 63,997 with NHL. NHL was diagnosed after RCC in 67 cases versus 59.8 expected (SIR 1.12, P = 0.19) and RCC after NHL in 96 cases versus 56.1 expected (SIR 1.71, P <0.0001). Only white males and females had a significantly increased risk of RCC after NHL, which was limited to the first year of follow-up. Excluding the first year of follow-up, NHL was diagnosed after RCC in 54 cases versus 49.3 expected (SIR 1.10, P = 0.27) and RCC after NHL in 54 cases versus 45.1 expected (SIR 1.20, P = 0.11).
When the first year of follow-up is excluded, there is no increased risk of NHL after RCC or vice versa.
确定在诊断出其他恶性肿瘤后非霍奇金淋巴瘤（NHL）和肾细胞癌（RCC）的发病率。
使用1973年至1994年的监测、流行病学和最终结果（SEER）数据库来确定每年RCC和NHL的年龄、性别、种族和日历年份特异性发病率。通过将这些发病率乘以年龄、性别、种族和日历年份特异性的风险人年数，得出每个性别、种族和随访期（少于1年、1至5年、5至10年以及10年或更长时间）的第二癌症预期数量，并将这些乘积在不同年龄组和日历年份求和。计算标准化发病率（SIR）（观察到的第二癌症数量/预期数量），使用泊松检验确定统计学意义。
1973年至1994年，SEER数据库中有32293人被诊断为RCC，63997人被诊断为NHL。NHL在RCC之后被诊断出67例，预期为59.8例（SIR 1.12，P = 0.19）；RCC在NHL之后被诊断出96例，预期为56.1例（SIR 1.71，P <0.0001）。只有白人男性和女性在患NHL后发生RCC的风险显著增加，且仅限于随访的第一年。排除随访的第一年，NHL在RCC之后被诊断出54例，预期为49.3例（SIR 1.10，P = 0.27）；RCC在NHL之后被诊断出54例，预期为45.1例（SIR 1.20，P = 0.11）。
排除随访的第一年，RCC后发生NHL的风险没有增加，反之亦然。
