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足月时疑似与非疑似小于胎龄儿的围产期结局

Suspected versus non-suspected small-for-gestational age fetuses at term: perinatal outcomes.

作者信息

Verlijsdonk Jan-Willem, Winkens Bjorn, Boers Kim, Scherjon Sicco, Roumen Frans

机构信息

Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, Netherlands.

出版信息

J Matern Fetal Neonatal Med. 2012 Jul;25(7):938-43. doi: 10.3109/14767058.2011.600793. Epub 2011 Sep 16.

Abstract

OBJECTIVE

To compare perinatal outcomes of suspected versus non-suspected small-for-gestational age fetuses (SGA) at term.

METHODS

Retrospective cohort study among all term singleton neonates with a birth weight <10th percentile born in the Parkstad region between 1 January 2006 and 3 March 2008. The subjects were assigned to a prenatally suspected or non-suspected SGA group. Primary outcome was adverse neonatal outcome at birth, defined as a composite of intrauterine fetal death, Apgar <7 at 5 min, or pH umbilical artery <7.05. Secondary outcome included neonatal medium care unit (NMCU) admission ≥ 7 days.

RESULTS

430 subjects were included in the study; 36.7% was suspected of SGA. In the suspected SGA group mean gestational age at birth and birth weight were significantly lower, whereas maternal morbidity was significantly higher. The incidence of labor induction and elective cesarean section were also significantly higher in the suspected SGA group. Total perinatal mortality was 2.1%. Identification of SGA and subsequent management led to a significant decrease of adverse neonatal outcome at birth, but did not lead to a significant decrease in NMCU admission ≥ 7 days.

CONCLUSIONS

Suspicion of SGA was associated with a more active management of labor and delivery, resulting in a better neonatal outcome at birth.

摘要

目的

比较足月时疑似与非疑似小于胎龄儿(SGA)的围产期结局。

方法

对2006年1月1日至2008年3月3日在帕克施塔德地区出生的所有出生体重低于第10百分位数的足月单胎新生儿进行回顾性队列研究。将研究对象分为产前疑似SGA组和非疑似SGA组。主要结局是出生时不良新生儿结局,定义为宫内胎儿死亡、5分钟时阿氏评分<7或脐动脉pH<7.05的综合情况。次要结局包括新生儿中级护理病房(NMCU)住院≥7天。

结果

430名研究对象纳入研究;36.7%被怀疑为SGA。在疑似SGA组中,出生时的平均孕周和出生体重显著较低,而孕产妇发病率显著较高。疑似SGA组引产和择期剖宫产的发生率也显著较高。围产期总死亡率为2.1%。SGA的识别及后续管理使出生时不良新生儿结局显著降低,但未使NMCU住院≥7天的情况显著减少。

结论

疑似SGA与更积极的分娩管理相关,从而在出生时获得更好的新生儿结局。

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