Minor Kathleen C, Bianco Katherine, Sie Lillian, Druzin Maurice L, Lee Henry C, Leonard Stephanie A
Division of Maternal-Fetal Medicine & Obstetrics, Department of Obstetrics and Gynecology, School of Medicine, Stanford University, Stanford, CA, US.
Department of Pediatrics, School of Medicine, Stanford University, Stanford, CA, US.
J Perinatol. 2023 Apr;43(4):437-444. doi: 10.1038/s41372-022-01544-w. Epub 2022 Oct 27.
Evaluate the association between small for gestational age (SGA) severity and morbidity and mortality in a contemporary, population of very preterm infants.
This secondary analysis of a California statewide database evaluated singleton infants born during 2008-2018 at 24-32 weeks' gestation, with a birthweight <15th percentile. We analyzed neonatal outcomes in relation to weight for gestational age (WGA) and symmetry of growth restriction.
An increase in WGA by one z-score was associated with decreased major morbidity or mortality risk (aRR 0.73, 95% CI 0.68-0.77) and other adverse outcomes. The association was maintained across gestational ages and did not differ by fetal growth restriction diagnosis. Symmetric growth restriction was not associated with neonatal outcomes after standardizing for gestational age at birth.
Increasing SGA severity had a significant impact on neonatal outcomes among very preterm infants.
评估当代极早产儿中小于胎龄（SGA）严重程度与发病率及死亡率之间的关联。
对加利福尼亚州全州数据库进行的这项二次分析评估了2008年至2018年期间孕24 - 32周出生、出生体重低于第15百分位数的单胎婴儿。我们分析了与胎龄体重（WGA）和生长受限对称性相关的新生儿结局。
WGA每增加一个z评分，主要发病率或死亡风险降低（调整后风险比0.73，95%置信区间0.68 - 0.77）以及其他不良结局风险降低。这种关联在各孕周均存在，且不因胎儿生长受限诊断而异。在对出生时的孕周进行标准化后，对称性生长受限与新生儿结局无关。
SGA严重程度增加对极早产儿的新生儿结局有显著影响。
