Novakov Mikic Aleksandra, Cabarkapa Velibor, Nikolic Aleksandra, Maric Daniela, Brkic Snezana, Mitic Gorana, Ristic Marina, Stosic Zoran
Clinical Centre of Vojvodina, Department of Obstetrics and Gynaecology, Novi Sad, Serbia.
J Matern Fetal Neonatal Med. 2012 Jul;25(7):961-5. doi: 10.3109/14767058.2011.601366. Epub 2012 Apr 5.
To evaluate diagnostic value of cystatin C serum levels as alternative marker of renal function in pre-eclamsia (PE) and compare it with the traditional markers of renal function, creatinine and uric acid. In order to investigate the possible influence of inflammation on biochemical markers of renal function, serum levels of high sensitive CRP were measured (hsCRP).
In this prospective study markers of kidney function were investigated in two groups of pregnant women: one with PE (n = 32) and the other of healthy pregnant women (n = 60). Serum cystatin C levels were measured as well as levels of traditional renal markers creatinin and uric acid and levels of high sensitive C-reactive protein.
Serum levels of cystatin C, creatinine and uric acid were significantly higher in the PE group than in the control group. Serum levels of hsCRP were higher in approximately the same number of patients with PE (50%) as in normal pregnancies (40%), without significant differences in CRP values between the two groups of patients.
Cystatin C serum level may have significant role as a marker of pre-eclampsia specially when used in combination with uric acid levels.
评估胱抑素C血清水平作为子痫前期（PE）肾功能替代标志物的诊断价值，并将其与传统肾功能标志物肌酐和尿酸进行比较。为了研究炎症对肾功能生化标志物的可能影响，检测了高敏CRP的血清水平（hsCRP）。
在这项前瞻性研究中，对两组孕妇的肾功能标志物进行了研究：一组为子痫前期患者（n = 32），另一组为健康孕妇（n = 60）。检测了血清胱抑素C水平以及传统肾脏标志物肌酐和尿酸水平以及高敏C反应蛋白水平。
子痫前期组血清胱抑素C、肌酐和尿酸水平显著高于对照组。子痫前期患者中hsCRP血清水平升高的人数（50%）与正常妊娠患者（40%）大致相同，两组患者的CRP值无显著差异。
胱抑素C血清水平可能作为子痫前期的标志物具有重要作用，特别是与尿酸水平联合使用时。
