Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.
Curr Pharm Biotechnol. 2012 Jul;13(9):1761-7. doi: 10.2174/138920112800958869.
Cancer Targeting Gene-Viro-Therapy (CTGVT) and Gene Armed Oncolytic Virus Therapy (GAOVT) both are identical by inserting an antitumor gene into an oncolytic virus. This approach has gradually become a hot topic in cancer therapy, because that CTGVT (GAOVT) has much higher antitumor than that of either gene therapy alone or oncolytic virotherapy alone. We proposed the CTGVT strategy in 1999-2001, insisted it as a long term systematic approach to be examined over 10 years and have published 68 SCI papers some in good Journals. The CD gene armed oncolytic adenovirus therapy (GAOVT) for cancer treatment with potent antitumor effect was also named in our laboratory in 2003. Several modifications to CTGVT will be carried out by our group and will be introduced briefly in this paper. Most importantly, the modifications of CTGVT usually resulted in complete eradication of xenograft tumors in nude mice. In future best antitumor drugs may emerge from the modified CTGVT strategy and not from either gene therapy or virotherapy alone.
癌症靶向基因-病毒治疗（CTGVT）和基因武装溶瘤病毒治疗（GAOVT）都是通过将抗肿瘤基因插入溶瘤病毒中来实现的。这种方法逐渐成为癌症治疗的热门话题，因为 CTGVT（GAOVT）比单独的基因治疗或单独的溶瘤病毒治疗具有更高的抗肿瘤活性。我们在 1999-2001 年提出了 CTGVT 策略，坚持将其作为一个长期的系统方法进行了 10 多年的研究，并发表了 68 篇 SCI 论文，其中一些发表在较好的期刊上。我们实验室在 2003 年还提出了用于癌症治疗的 CD 基因武装溶瘤腺病毒治疗（GAOVT），具有很强的抗肿瘤作用。我们小组将对 CTGVT 进行一些改进，并在本文中进行简要介绍。最重要的是，CTGVT 的改进通常导致裸鼠异种移植肿瘤的完全消除。在未来，最好的抗肿瘤药物可能来自于改进的 CTGVT 策略，而不是来自于单独的基因治疗或病毒治疗。
