Çetinkaya Melisa, Baran Yusuf
Department of Molecular Biology and Genetics, Faculty of Science, İzmir Institute of Technology, İzmir 35430, Turkey.
Vaccines (Basel). 2023 Feb 27;11(3):554. doi: 10.3390/vaccines11030554.
Cancer is a global concern, as the rate of incidence is increasing each year. The challenges related to the current chemotherapy drugs, such as the concerns related to toxicity, turn to cancer therapeutic research to discover alternative therapy strategies that are less toxic to normal cells. Among those studies, the use of flavonoids-natural compounds produced by plants as secondary metabolites for cancer therapy-has been a hot topic in cancer treatment. Luteolin, a flavonoid that has been present in many fruits, vegetables, and herbs, has been identified to exhibit numerous biological activities, including anti-inflammatory, antidiabetic, and anticancer properties. The anticancer property of Luteolin has been extensively researched in many cancer types and has been related to its ability to inhibit tumor growth by targeting cellular processes such as apoptosis, angiogenesis, migration, and cell cycle progression. It achieves this by interacting with various signaling pathways and proteins. In the current review, the molecular targets of Luteolin as it exerts its anticancer properties, the combination therapy that includes Luteolin with other flavonoids or chemotherapeutic drugs, and the nanodelivery strategies for Luteolin are described for several cancer types.
癌症是一个全球性问题，因为其发病率逐年上升。当前化疗药物存在诸多挑战，比如毒性相关问题，这促使癌症治疗研究去探寻对正常细胞毒性较小的替代治疗策略。在这些研究中，使用黄酮类化合物（植物产生的作为次生代谢产物的天然化合物用于癌症治疗）一直是癌症治疗领域的热门话题。木犀草素是一种存在于许多水果、蔬菜和草药中的黄酮类化合物，已被证实具有多种生物学活性，包括抗炎、抗糖尿病和抗癌特性。木犀草素的抗癌特性已在多种癌症类型中得到广泛研究，并且与其通过靶向细胞凋亡、血管生成、迁移和细胞周期进程等细胞过程来抑制肿瘤生长的能力有关。它通过与各种信号通路和蛋白质相互作用来实现这一点。在当前的综述中，针对几种癌症类型描述了木犀草素发挥抗癌特性的分子靶点、包含木犀草素与其他黄酮类化合物或化疗药物的联合治疗，以及木犀草素的纳米递送策略。
