Department of Pathology, Dartmouth Medical School, Lebanon, NH 03756, U.S.A.
ASN Neuro. 2011 Aug 3;3(3):e00063. doi: 10.1042/AN20110014.
GBM (glioblastoma multiforme) is a highly aggressive brain tumour with very poor prognosis despite multi-modalities of treatment. Furthermore, recent failure of targeted therapy for these tumours highlights the need of appropriate rodent models for preclinical studies. In this review, we highlight the most commonly used rodent models (U251, U86, GL261, C6, 9L and CNS-1) with a focus on the pathological and genetic similarities to the human disease. We end with a comprehensive review of the CNS-1 rodent model.
GBM（多形性胶质母细胞瘤）是一种高度侵袭性的脑肿瘤，尽管采用了多种治疗方法，但预后仍然很差。此外，最近针对这些肿瘤的靶向治疗失败凸显了临床前研究中需要合适的啮齿动物模型。在这篇综述中，我们重点介绍了最常用的啮齿动物模型（U251、U86、GL261、C6、9L 和 CNS-1），并强调了它们与人类疾病在病理学和遗传学上的相似性。最后，我们对 CNS-1 啮齿动物模型进行了全面的综述。
