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N-acetylaspartylglutamate is an agonist at mGluR₃ in vivo and in vitro.

作者信息

Neale Joseph H

出版信息

J Neurochem. 2011 Dec;119(5):891-5. doi: 10.1111/j.1471-4159.2011.07380.x.

DOI:10.1111/j.1471-4159.2011.07380.x
PMID:21740441
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3202081/
Abstract
摘要

相似文献

1
N-acetylaspartylglutamate is an agonist at mGluR₃ in vivo and in vitro.N-乙酰天门冬氨酰谷氨酸在体内和体外都是代谢型谷氨酸受体3(mGluR₃)的激动剂。
J Neurochem. 2011 Dec;119(5):891-5. doi: 10.1111/j.1471-4159.2011.07380.x.
2
N-acetylaspartylglutamate is not demonstrated to be a selective mGlu₃receptor agonist.
J Neurochem. 2011 Dec;119(5):896-8. doi: 10.1111/j.1471-4159.2011.07480.x.
3
The neuroactive peptide N-acetylaspartylglutamate is not an agonist at the metabotropic glutamate receptor subtype 3 of metabotropic glutamate receptor.神经活性肽N-乙酰天门冬氨酰谷氨酸不是代谢型谷氨酸受体亚型3的代谢型谷氨酸受体激动剂。
J Pharmacol Exp Ther. 2009 Jul;330(1):212-9. doi: 10.1124/jpet.109.152553. Epub 2009 Apr 23.
4
beta-NAAG rescues LTP from blockade by NAAG in rat dentate gyrus via the type 3 metabotropic glutamate receptor.β-N-乙酰天门冬氨酸谷氨酸(beta-NAAG)通过3型代谢型谷氨酸受体挽救大鼠齿状回中由N-乙酰天门冬氨酸谷氨酸(NAAG)引起的长时程增强阻断。
J Neurophysiol. 2001 Mar;85(3):1097-106. doi: 10.1152/jn.2001.85.3.1097.
5
Advances in understanding the peptide neurotransmitter NAAG and appearance of a new member of the NAAG neuropeptide family.深入了解肽神经递质 NAAG 及其新型神经肽家族成员的出现。
J Neurochem. 2011 Aug;118(4):490-8. doi: 10.1111/j.1471-4159.2011.07338.x. Epub 2011 Jul 1.
6
N-Acetylaspartylglutamate: the most abundant peptide neurotransmitter in the mammalian central nervous system.N-乙酰天门冬氨酰谷氨酸:哺乳动物中枢神经系统中含量最丰富的肽类神经递质。
J Neurochem. 2000 Aug;75(2):443-52. doi: 10.1046/j.1471-4159.2000.0750443.x.
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Effects of N-acetylaspartylglutamate (NAAG) at group II mGluRs and NMDAR.N-乙酰天门冬氨酰谷氨酸(NAAG)对II型代谢型谷氨酸受体(mGluRs)和N-甲基-D-天冬氨酸受体(NMDAR)的作用。
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N-acetylaspartylglutamate selectively activates mGluR3 receptors in transfected cells.N-乙酰天门冬氨酰谷氨酸在转染细胞中选择性激活代谢型谷氨酸受体3(mGluR3)。
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Regional distribution and pharmacological characteristics of [3H]N-acetyl-aspartyl-glutamate (NAAG) binding sites in rat brain.大鼠脑中[3H]N-乙酰天冬氨酰谷氨酸(NAAG)结合位点的区域分布及药理学特性
Neurochem Int. 2001 Jan;38(1):53-62. doi: 10.1016/s0197-0186(00)00045-0.
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Regulation of glutamate carboxypeptidase II hydrolysis of N-acetylaspartylglutamate (NAAG) in crayfish nervous tissue is mediated by glial glutamate and acetylcholine receptors.小龙虾神经组织中谷氨酸羧肽酶II对N-乙酰天门冬氨酰谷氨酸(NAAG)的水解调节由神经胶质谷氨酸和乙酰胆碱受体介导。
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Group II Metabotropic Glutamate Receptors Reduce Apoptosis and Regulate BDNF and GDNF Levels in Hypoxic-Ischemic Injury in Neonatal Rats.II 型代谢型谷氨酸受体可减少新生大鼠缺氧缺血性损伤中的细胞凋亡,并调节脑源性神经营养因子和胶质细胞源性神经营养因子的水平。
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Glutamate Metabotropic Receptor Type 3 (mGlu3) Localization in the Rat Prelimbic Medial Prefrontal Cortex.3型代谢型谷氨酸受体(mGlu3)在大鼠前边缘内侧前额叶皮质中的定位
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Dendrimer-2PMPA Delays Muscle Function Loss and Denervation in a Murine Model of Amyotrophic Lateral Sclerosis.树状聚合物 2PMPA 延缓肌萎缩侧索硬化症小鼠模型的肌肉功能丧失和去神经支配。
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本文引用的文献

1
Advances in understanding the peptide neurotransmitter NAAG and appearance of a new member of the NAAG neuropeptide family.深入了解肽神经递质 NAAG 及其新型神经肽家族成员的出现。
J Neurochem. 2011 Aug;118(4):490-8. doi: 10.1111/j.1471-4159.2011.07338.x. Epub 2011 Jul 1.
2
N-acetylaspartylglutamate synthetase II synthesizes N-acetylaspartylglutamylglutamate.N-乙酰天门冬氨酸谷氨酸合成酶 II 合成 N-乙酰天门冬氨酸谷氨酸。
J Biol Chem. 2011 May 13;286(19):16693-706. doi: 10.1074/jbc.M111.230136. Epub 2011 Mar 25.
3
Endogenous N-acetylaspartylglutamate (NAAG) inhibits synaptic plasticity/transmission in the amygdala in a mouse inflammatory pain model.内源性 N-乙酰天冬氨酸谷氨酸盐 (NAAG) 在小鼠炎症痛模型中抑制杏仁核中的突触可塑性/传递。
Mol Pain. 2010 Sep 22;6:60. doi: 10.1186/1744-8069-6-60.
4
Sensing G protein-coupled receptor activation.感应 G 蛋白偶联受体的激活。
Neuropharmacology. 2011 Jan;60(1):45-51. doi: 10.1016/j.neuropharm.2010.08.006. Epub 2010 Aug 18.
5
Metabotropic glutamate receptors: physiology, pharmacology, and disease.代谢型谷氨酸受体:生理学、药理学和疾病。
Annu Rev Pharmacol Toxicol. 2010;50:295-322. doi: 10.1146/annurev.pharmtox.011008.145533.
6
The neuroactive peptide N-acetylaspartylglutamate is not an agonist at the metabotropic glutamate receptor subtype 3 of metabotropic glutamate receptor.神经活性肽N-乙酰天门冬氨酰谷氨酸不是代谢型谷氨酸受体亚型3的代谢型谷氨酸受体激动剂。
J Pharmacol Exp Ther. 2009 Jul;330(1):212-9. doi: 10.1124/jpet.109.152553. Epub 2009 Apr 23.
7
Effects of N-acetylaspartylglutamate (NAAG) at group II mGluRs and NMDAR.N-乙酰天门冬氨酰谷氨酸(NAAG)对II型代谢型谷氨酸受体(mGluRs)和N-甲基-D-天冬氨酸受体(NMDAR)的作用。
Neuropharmacology. 2009 May-Jun;56(6-7):1060-7. doi: 10.1016/j.neuropharm.2009.03.002. Epub 2009 Mar 12.
8
Glutamatergic inhibition in sensory neocortex.感觉新皮层中的谷氨酸能抑制作用。
Cereb Cortex. 2009 Oct;19(10):2281-9. doi: 10.1093/cercor/bhn246. Epub 2009 Jan 28.
9
Intracerebroventricular administration of N-acetylaspartylglutamate (NAAG) peptidase inhibitors is analgesic in inflammatory pain.脑室内注射N-乙酰天冬氨酰谷氨酸(NAAG)肽酶抑制剂对炎性疼痛具有镇痛作用。
Mol Pain. 2008 Aug 1;4:31. doi: 10.1186/1744-8069-4-31.
10
Progress in the discovery and development of glutamate carboxypeptidase II inhibitors.谷氨酸羧肽酶II抑制剂的发现与开发进展
Drug Discov Today. 2007 Sep;12(17-18):767-76. doi: 10.1016/j.drudis.2007.07.010. Epub 2007 Aug 27.