Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, Davis, CA, USA.
Cell Microbiol. 2011 Nov;13(11):1639-47. doi: 10.1111/j.1462-5822.2011.01637.x. Epub 2011 Jul 11.
Non-typhoidal Salmonella (NTS) serotypes cause a localized gastroenteritis in immunocompetent individuals. In contrast, primary immunodeficiencies that impair interleukin-23 (IL-23)-dependent pathways are associated in humans with disseminated NTS bloodstream infections (bacteraemia). The recent use of animal models has helped to define the role the IL-23 axis plays during NTS gastroenteritis, but additional work is needed to elucidate how this host defence pathway prevents NTS bacteraemia.
非伤寒型沙门氏菌（NTS）血清型在免疫功能正常的个体中引起局部胃肠炎。相比之下，原发性免疫缺陷病会损害白细胞介素-23（IL-23）依赖途径，而人类则与 NTS 血行感染（菌血症）有关。最近使用动物模型有助于确定 IL-23 轴在 NTS 胃肠炎中的作用，但仍需要进一步的研究来阐明宿主防御途径如何防止 NTS 菌血症。
