中国队列中活体供肾移植后供受者的肾功能。

Renal function of donors and recipients after living donor kidney transplantation in a Chinese cohort.

机构信息

Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.

出版信息

Chin Med J (Engl). 2011 May;124(9):1290-5.

PMID:21740735

Abstract

BACKGROUND

Living donor kidney transplantation (LKT) has been booming in China. This study aimed to elucidate the renal function of both Chinese donors and recipients after the donation and transplantation.

METHODS

One hundred and forty-one pairs of donors and recipients for LKT were randomly selected and followed up for up to seven years. The donors' and recipients' renal function was recorded before and after operation.

RESULTS

The donors presented a mean age of (43.9 ± 7.5) years at donation. The female contributed 101/141 (71.6%) in all donors, and no effect was shown between genders on healthy donors' renal function. The donors' glomerular filtration rates (GFR) were (119.5 ± 20.4) ml/min, (85.2 ± 17.6) ml/min, (87.2 ± 15.9) ml/min, (82.1 ± 14.6) ml/min and (83.0 ± 13.7) ml/min preoperatively, and for five days, three months, one year and beyond one year after the operation. The donors for the period of 1 - 3 years, 3 - 5 years and more than 5 years after donation showed GFR as (83.9 ± 12.7) ml/min, (83.0 ± 17.6) ml/min, and (80.9 ± 20.8) ml/min, respectively, no statistically significant difference was found. Moreover, no significant clinical changes in blood pressure and proteinuria were found among the donors. In the recipients, delayed graft function (DGF) rate was 6.4%, acute rejection rate was 11.3%, and GFR were (66.5 ± 16.4) ml/min, (73.2 ± 19.6) ml/min and (63.9 ± 18.6) ml/min respectively at three months, one year and beyond one year post-transplantation respectively.

CONCLUSION

The donors/recipients of LKT in Chinese population experience well-functioning remaining/donor kidneys.

摘要

背景

在中国，活体供肾移植（LKT）蓬勃发展。本研究旨在阐明供体和受体接受捐赠和移植后的肾功能。

方法

随机选择 141 对接受 LKT 的供体和受体进行随访，最长达 7 年。记录供体和受体手术前后的肾功能。

结果

供体在捐赠时的平均年龄为（43.9 ± 7.5）岁。在所有供体中，女性占 101/141（71.6%），性别对健康供体的肾功能没有影响。供体的肾小球滤过率（GFR）分别为术前（119.5 ± 20.4）ml/min、术后 5 天（85.2 ± 17.6）ml/min、术后 3 个月（87.2 ± 15.9）ml/min、术后 1 年（82.1 ± 14.6）ml/min和术后 1 年以上（83.0 ± 13.7）ml/min。供体在捐赠后 1-3 年、3-5 年和 5 年以上的 GFR 分别为（83.9 ± 12.7）ml/min、（83.0 ± 17.6）ml/min和（80.9 ± 20.8）ml/min，差异无统计学意义。此外，供体的血压和蛋白尿无明显临床变化。在受者中，延迟移植物功能（DGF）发生率为 6.4%，急性排斥反应发生率为 11.3%，移植后 3 个月、1 年和 1 年以上的 GFR 分别为（66.5 ± 16.4）ml/min、（73.2 ± 19.6）ml/min和（63.9 ± 18.6）ml/min。