Genetics Center, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan.
Clin Chim Acta. 2011 Oct 9;412(21-22):1899-904. doi: 10.1016/j.cca.2011.06.020. Epub 2011 Jun 29.
Membranous glomerulonephritis (MGN) is one of common causes of idiopathic nephrotic syndrome in adults, and 25% of MGN patients proceed to end-stage renal disease. STAT4 gene polymorphisms have been reported to be associated with many inflammatory diseases. The objective of this study was to clarify the relationship between STAT4 gene polymorphisms and the pathogenesis of MGN.
We investigated the association of three STAT4 gene polymorphisms (rs3024912, rs3024908, and rs3024877) with the susceptibility to MGN in 403 Taiwanese populations (138 MGN patients and 265 controls).
The results indicated that the statistically significant difference in genotype frequency distribution was found at rs3024908 SNP in MGN patients and control groups (p=0.014). In addition, the individuals with the GG genotype at rs3024912 SNP may have a higher risk in kidney failure of MGN patients (adjusted odds ratio [OR]=3.255; 95% confidence interval [CI]=1.155-9.176, p=0.026).
Our data provide a new information that the STAT4 (rs3024912 and rs3024908) polymorphisms may be the underlying cause of MGN, and these polymorphisms revealed by this study warrant further investigation.
膜性肾小球肾炎（MGN）是成人特发性肾病综合征的常见病因之一，25%的 MGN 患者进展为终末期肾病。STAT4 基因多态性与许多炎症性疾病有关。本研究旨在阐明 STAT4 基因多态性与 MGN 发病机制的关系。
我们调查了三个 STAT4 基因多态性（rs3024912、rs3024908 和 rs3024877）与 403 名台湾人群（138 名 MGN 患者和 265 名对照者）易患 MGN 的相关性。
结果表明，MGN 患者和对照组在 rs3024908 SNP 的基因型频率分布存在统计学显著差异（p=0.014）。此外，rs3024912 SNP 中 GG 基因型的个体可能患有 MGN 患者肾衰竭的更高风险（调整后的优势比[OR]=3.255；95%置信区间[CI]=1.155-9.176，p=0.026）。
我们的数据提供了新的信息，即 STAT4（rs3024912 和 rs3024908）多态性可能是 MGN 的潜在原因，本研究揭示的这些多态性值得进一步研究。
