Shenzhen Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Shenzhen Third People's Hospital, Guangdong Medical College, Shenzhen, China.
Cell Immunol. 2011;270(2):217-23. doi: 10.1016/j.cellimm.2011.05.009. Epub 2011 Jun 17.
Although it has been recognized that ectopic follicle-like B cell aggregate formation is common in the lungs of patients with tuberculosis, the role of infiltrated B cells in human tuberculosis remains to be elucidated. In the present study, we showed that ectopic B cell aggregate formation was associated with containment of Mycobacterium tuberculosis. The area ratio of ectopic B cell aggregates was correlated with localized IL-17 mRNA expression and peripheral TGF-β and IL-6 mRNA expression. Depletion of B cells from pleural fluid mononuclear cells resulted in significantly diminished M. tuberculosis antigen-specific IL-17 and IL-22 production, but not in IFN-γ secretion. Therefore, ectopic lung B cell formation is important for containment of M. tuberculosis, and up-regulation of IL-17 and IL-22 responses may be an important mechanism underlying the protective role B cells in human tuberculosis.
虽然已经认识到，在结核患者的肺部中，异位滤泡样 B 细胞聚集的形成很常见，但浸润 B 细胞在人类结核病中的作用仍有待阐明。在本研究中，我们表明异位 B 细胞聚集的形成与结核分枝杆菌的局限化有关。异位 B 细胞聚集的面积比与局部 IL-17 mRNA 表达以及外周 TGF-β和 IL-6 mRNA 表达相关。从胸腔液单核细胞中耗竭 B 细胞会导致结核分枝杆菌抗原特异性 IL-17 和 IL-22 产生显著减少，但 IFN-γ 的分泌不受影响。因此，异位肺 B 细胞的形成对于结核分枝杆菌的局限化很重要，IL-17 和 IL-22 反应的上调可能是 B 细胞在人类结核病中发挥保护作用的重要机制。
