Laboratoire de Radioécologie et d'Ecotoxicologie, Institut de Radioprotection et de Sûreté Nucléaire, Cadarache, Bat 186, BP3, 13115 Saint-Paul-lez-Durance Cedex, France.
J Environ Radioact. 2011 Nov;102(11):1039-44. doi: 10.1016/j.jenvrad.2011.06.004. Epub 2011 Jul 7.
Eggs/larval of freshwater fish (Danio rerio) were exposed to low dose rates of external gamma radiation (from 1 to 1000 mGy d(-1)) over a 20-day period, with the objective of testing the appropriateness of the 10 mGy d(-1) guideline suggested by the IAEA. The present study examines different endpoints, mortality and hatching time and success of embryos as well as the genotoxicity of γ-irradiations (after 48 h). The 20-day embryo-larval bioassay showed an enhanced larval resistance to starvation after chronic exposure to γ irradiation (from low 1 mGy d(-1) to high dose rate 1000 mGy d(-1)) and an acceleration in hatching time. Gamma irradiation led to increased genotoxic damage Ito zebrafish egg (40-50% DNA in tail in Comet assay) from the lowest dose rate (1 mGy d(-1)). Possible mechanisms of γ radiotoxicity and implications for radioprotection are discussed.
将淡水鱼（斑马鱼）的卵/幼虫在 20 天的时间内暴露于低剂量率的外部γ辐射（从 1 到 1000 mGy d(-1))，以测试 IAEA 提出的 10 mGy d(-1) 指导值是否合适。本研究检查了不同的终点，死亡率和孵化时间以及胚胎的成功率以及γ辐射的遗传毒性（48 小时后）。20 天的胚胎-幼虫生物测定显示，慢性暴露于γ辐射（从低剂量率 1 mGy d(-1)到高剂量率 1000 mGy d(-1))后，幼虫对饥饿的抵抗力增强，孵化时间加快。γ辐射导致斑马鱼卵的遗传毒性损伤增加（彗星试验中尾巴的 DNA 占 40-50%），最低剂量率（1 mGy d(-1)）。讨论了γ辐射毒性的可能机制及其对辐射防护的影响。
