Department of Biochemistry and Molecular Biology, State Key Laboratory of Cancer Biology, The Fourth Military Medical University, Xi'an 710032, PR China.
Cancer Lett. 2011 Nov 1;310(1):94-100. doi: 10.1016/j.canlet.2011.06.015. Epub 2011 Jun 24.
N-myc downstream regulated gene 2 (NDRG2) is involved in invasion and metastasis of cancer, furthermore it is frequently down-regulated in prostate cancer. Herein we evaluated the effect of NDRG2 overexpression on invasiveness and bone destruction in prostate cancer. The human prostate cancer cell line PC-3 and DU145 were infected with Ad-NDRG2 or Ad-LacZ. Overexpression of NDRG2 not only inhibited the growth of the cells, but also suppressed invasiveness of the cells in an in vitro assay. PC-3 cells infected with Ad-NDRG2 or Ad-LacZ were injected into the tibias of nude mice. Four weeks later, we found the mice injected with PC-3 cells overexpressing NDRG2 had smaller tumors and less bone destruction. These results demonstrate that NDRG2 overexpression can inhibit tumor growth and invasion, furthermore, it can decrease bone destruction caused by prostate cancer bone metastasis.
N- MYC 下游调节基因 2（NDRG2）参与癌症的侵袭和转移，此外，它在前列腺癌中经常下调。在此，我们评估了 NDRG2 过表达对前列腺癌细胞侵袭和骨破坏的影响。用人前列腺癌细胞系 PC-3 和 DU145 感染 Ad-NDRG2 或 Ad-LacZ。NDRG2 的过表达不仅抑制了细胞的生长，而且在体外实验中还抑制了细胞的侵袭性。将感染了 Ad-NDRG2 或 Ad-LacZ 的 PC-3 细胞注入裸鼠的胫骨中。4 周后，我们发现注射了过表达 NDRG2 的 PC-3 细胞的小鼠肿瘤较小，骨破坏较少。这些结果表明，NDRG2 的过表达可以抑制肿瘤的生长和侵袭，此外，还可以减少前列腺癌骨转移引起的骨破坏。
