Faculty of Veterinary Medicine and Animal Science, Department of Surgery, University of São Paulo, São Paulo 05508-270, São Paulo, Brazil.
Burns. 2011 Nov;37(7):1192-201. doi: 10.1016/j.burns.2011.05.016. Epub 2011 Jul 7.
Burns are serious consequences of trauma in terms of both imminent mortality and prolonged periods of morbidity. They are often accompanied by unsatisfactory cosmetic as well as functional and psychological outcomes. These complications emphasise the need for stronger efforts in achieving greater diversity and effectiveness in the treatment of skin burns. This study aimed to verify the effectiveness of gross and microscopic epidermal and dermal responses in the process of regenerative repair or healing of burns in rats that were treated either daily with 5% propolis ointment or by autologous amnion graft. Second-degree burns were inflicted in the neck region of female rats by contact with a hot metal (at 130 °C) for 5 s. Propolis treatment accelerated the process of tissue repair and led to decreased local inflammation, which indicates that treatment with propolis was successful in the initial period (7 days) and stimulated the production of collagen fibre (assessed by morphometry) in all the periods evaluated (14 and 21 days). Amnion treatment inhibited local inflammation (assessed macroscopically), stimulated local epithelial regeneration (assessed microscopically) and stimulated the production of collagen fibre (assessed by morphometry) in the days following burn. These treatments offer new therapeutic strategies for treating severe skin burns; these strategies may allow the minimisation of scar formation, a more rapid return of function and, ultimately, a better quality of life for burn patients.
烧伤是创伤的严重后果，不仅有即刻死亡的风险，还会导致长时间的发病。烧伤常伴有不理想的美容效果，以及功能和心理方面的不良后果。这些并发症强调了需要更加努力地实现皮肤烧伤治疗的更大多样性和有效性。本研究旨在验证在接受 5%蜂胶软膏每日治疗或自体羊膜移植治疗的大鼠中，表皮和真皮的大体和微观表皮和真皮反应在烧伤再生修复或愈合过程中的有效性。通过接触 130°C 的热金属（5 s）在雌性大鼠颈部造成二度烧伤。蜂胶治疗加速了组织修复过程，并减少了局部炎症，这表明在最初的 7 天内，蜂胶治疗是成功的，并刺激了胶原蛋白纤维的产生（通过形态计量学评估），在所有评估的时期（14 天和 21 天）。羊膜治疗抑制了局部炎症（宏观评估），刺激了局部上皮再生（微观评估），并在烧伤后刺激了胶原蛋白纤维的产生（通过形态计量学评估）。这些治疗方法为治疗严重皮肤烧伤提供了新的治疗策略；这些策略可能有助于减少疤痕形成，更快地恢复功能，最终提高烧伤患者的生活质量。
