Institute for Biochemistry, University of Stuttgart, Pfaffenwaldring 55, 70569 Stuttgart, Germany.
Trends Biochem Sci. 2011 Oct;36(10):515-23. doi: 10.1016/j.tibs.2011.06.001. Epub 2011 Jul 7.
Cdc48 is an essential, highly prominent ATP driven machine in eukaryotic cells. Physiological function of Cdc48 has been found in a multitude of cellular processes, for instance cell cycle progression, homotypic membrane fusion, chromatin remodeling, transcriptional and metabolic regulation, and many others. The molecular function of Cdc48 is arguably best understood in endoplasmic reticulum-associated protein degradation by the ubiquitin proteasome system. In this review, we summarize the general characteristics of Cdc48/p97 and the most recent results on the molecular function of Cdc48 in some of the above processes, which were found to finally end in proteolysis-connected pathways, either involving the proteasome or autophagocytosis-mediated lysosomal degradation.
CDC48 是真核细胞中一种必需的、高度突出的 ATP 驱动机器。CDC48 的生理功能已在多种细胞过程中被发现，例如细胞周期进展、同源膜融合、染色质重塑、转录和代谢调节等。CDC48 的分子功能在泛素蛋白酶体系统介导的内质网相关蛋白降解中得到了很好的理解。在这篇综述中，我们总结了 CDC48/p97 的一般特征，以及最近关于 CDC48 在上述一些过程中的分子功能的结果，这些结果最终都通向与蛋白水解相关的途径，这些途径要么涉及蛋白酶体，要么涉及自噬体介导的溶酶体降解。
