Dargemont Catherine, Ossareh-Nazari Batool
CNRS, UMR7592, Institut Jacques Monod, Univ Paris Diderot, Sorbonne Paris Cité, 75205 Paris, France.
Biochim Biophys Acta. 2012 Jan;1823(1):138-44. doi: 10.1016/j.bbamcr.2011.07.011. Epub 2011 Jul 23.
The AAA-ATPase Cdc48/p97 controls a large array of cellular functions including protein degradation, cell division, membrane fusion through its ability to interact with and control the fate of ubiquitylated proteins. More recently, Cdc48/p97 also appeared to be involved in autophagy, a catabolic cell response that has long been viewed as completely distinct from the Ubiquitine/Proteasome System. In particular, conjugation by ubiquitin or ubiquitin-like proteins as well as ubiquitin binding proteins such as Cdc48/p97 and its cofactors can target degradation by both catabolic pathways. This review will focus on the recently described functions of Cdc48/p97 in autophagosome biogenesis as well as selective autophagy.
AAA-ATP酶Cdc48/p97通过与泛素化蛋白相互作用并控制其命运，从而调控大量细胞功能，包括蛋白质降解、细胞分裂和膜融合。最近，Cdc48/p97似乎也参与了自噬过程，自噬是一种分解代谢的细胞反应，长期以来一直被认为与泛素/蛋白酶体系统完全不同。特别是，泛素或类泛素蛋白的缀合以及诸如Cdc48/p97及其辅因子等泛素结合蛋白，可通过这两种分解代谢途径靶向降解。本综述将聚焦于Cdc48/p97在自噬体生物发生以及选择性自噬方面最近被描述的功能。
