Department of Chemistry, University of Mysore, Manasagangotri, Mysore 570 006, Karnataka, India.
Spectrochim Acta A Mol Biomol Spectrosc. 2011 Oct 15;81(1):276-82. doi: 10.1016/j.saa.2011.06.010. Epub 2011 Jun 22.
Four Schiff base ligands and their corresponding organotin(IV) complexes have been synthesized and characterized by elemental analyses, IR, (1)H NMR, MS and thermal studies. The Schiff bases are obtained by the condensation of 3-amino-2-methyl-4(3H)-quinazolinone with different substituted aldehydes. The elemental analysis data suggest the stoichiometry to be 1:1 ratio formation. Infrared spectral data agreed with the coordination to the central metal ion through imine nitrogen, lactam oxygen and deprotonated phenolic oxygen atoms. All the synthesized compounds have been evaluated for antimicrobial activity against selected species of microorganisms. In addition, DNA binding/cleavage capacity of the compounds was analyzed by absorption spectroscopy, viscosity measurements and gel electrophoresis methods.
四种席夫碱配体及其相应的有机锡（IV）配合物已经通过元素分析、IR、（1）H NMR、MS 和热研究进行了合成和表征。席夫碱是通过 3-氨基-2-甲基-4(3H)-喹唑啉酮与不同取代的醛缩合得到的。元素分析数据表明，其化学计量比为 1:1 比形成。红外光谱数据表明，通过亚胺氮、内酰胺氧和去质子酚氧原子与中心金属离子配位。所有合成的化合物都已针对选定的微生物物种进行了抗微生物活性评估。此外，还通过吸收光谱、粘度测量和凝胶电泳方法分析了化合物的 DNA 结合/切割能力。
