Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Cancer Cell. 2011 Jul 12;20(1):1-2. doi: 10.1016/j.ccr.2011.06.025.
TET2 encodes an enzyme that hydroxylates methylcytosine and is frequently targeted by loss-of-function mutations in myelodysplasia, myeloproliferative disorders, and acute myeloid leukemia. In this issue of Cancer Cell, two studies show that inactivation of Tet2 enhances hematopoietic stem cell self renewal and promotes the development of myeloproliferative disorders.
TET2 编码一种能够将甲基胞嘧啶羟化的酶，其功能丧失突变在骨髓增生异常、骨髓增殖性疾病和急性髓系白血病中经常被靶向。在本期《癌细胞》中，两项研究表明 Tet2 的失活增强了造血干细胞的自我更新能力，并促进了骨髓增殖性疾病的发展。
