Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
Neurobiol Aging. 2011 Nov;32(11):2106.e1-6. doi: 10.1016/j.neurobiolaging.2011.05.016. Epub 2011 Jul 8.
We examined apolipoprotein E (ApoE) genotypes in relation to Parkinson's disease (PD) among 786 cases and 1537 controls, all non-Hispanic Caucasians. Odds ratios (ORs) and 95% confidence intervals (CIs) were derived from multivariate logistic regression models, adjusting for year of birth, sex, smoking status, daily caffeine intake, and family history of PD. Compared with participants with ApoE ε33, ε4 carriers (ε34/ε44) had significantly lower odds for having PD (OR, 0.75; 95% CI, 0.59-0.94; p = 0.01), whereas ε2 carriers (ε23/ε22) did not (OR, 0.95; 95% CI, 0.73-1.24; p = 0.71). Subgroup analyses showed similar results. In addition, we conducted a meta-analysis which confirmed our primary findings (ε34/ε44 vs. ε33: OR, 0.90; 95% CI, 0.81-0.99; p = 0.024 and ε23/ε22 vs. ε33: OR, 1.10; 95% CI, 0.97-1.23; p = 0.13). In PD patients, the prevalence of dementia appeared to be higher among ε4 carriers (compared with ε33: OR, 1.59; 95% CI, 0.98-2.58; p = 0.06), but lower among ε2 carriers (OR, 0.75; 95% CI, 0.40-1.42; p = 0.38), although neither test was statistically significant. Our study suggested that the ApoE ε4 allele may be associated with a lower PD risk among non-Hispanic Caucasians.
我们在 786 例病例和 1537 例对照（均为非西班牙裔白种人）中研究了载脂蛋白 E（ApoE）基因型与帕金森病（PD）的关系。通过多变量逻辑回归模型，调整出生年份、性别、吸烟状况、每日咖啡因摄入量和 PD 家族史，得出比值比（OR）和 95％置信区间（CI）。与携带 ApoE ε33 的参与者相比，ε4 携带者（ε34/ε44）发生 PD 的几率明显降低（OR，0.75；95％CI，0.59-0.94；p = 0.01），而 ε2 携带者（ε23/ε22）则没有（OR，0.95；95％CI，0.73-1.24；p = 0.71）。亚组分析显示出相似的结果。此外，我们进行了荟萃分析，证实了我们的主要发现（ε34/ε44 与 ε33：OR，0.90；95％CI，0.81-0.99；p = 0.024 和 ε23/ε22 与 ε33：OR，1.10；95％CI，0.97-1.23；p = 0.13）。在 PD 患者中，痴呆的患病率似乎在 ε4 携带者中更高（与 ε33 相比：OR，1.59；95％CI，0.98-2.58；p = 0.06），而在 ε2 携带者中更低（OR，0.75；95％CI，0.40-1.42；p = 0.38），尽管两者均无统计学意义。我们的研究表明，ApoE ε4 等位基因可能与非西班牙裔白种人中 PD 风险降低有关。
