Division of Allergy and Clinical Immunology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Oor-Por-Ror Building, Bangkok 10330, Thailand.
Trends Mol Med. 2011 Oct;17(10):604-11. doi: 10.1016/j.molmed.2011.05.014. Epub 2011 Jul 7.
House dust mite (HDM) allergy is a frequent inflammatory disease found worldwide. Although allergen-specific CD4(+) Th2 cells orchestrate the HDM allergic response, notably through induction of IgE directed towards mite allergens, recent studies have demonstrated that innate immunity activation also plays a critical role in HDM-induced allergy pathogenesis. HDM allergens can not only be considered proteins that induce adaptive Th2-biased responses in susceptible subjects but also as strong activators of innate immune cells, including skin keratinocytes and airway epithelial cells. The contribution of microbial adjuvant factors, derived from HDM carriers or the environment, is also essential in such cell stimulation. This review highlights how HDM allergens, together with microbial compounds, promote allergic responses through pattern recognition receptor-dependent pathways.
屋尘螨（HDM）过敏是一种在全球范围内普遍存在的炎症性疾病。虽然过敏原特异性 CD4+Th2 细胞通过诱导针对螨变应原的 IgE 来调控 HDM 过敏反应，但最近的研究表明，固有免疫激活也在 HDM 诱导的过敏发病机制中起着关键作用。HDM 过敏原不仅可以被认为是诱导易感宿主产生适应性 Th2 偏向性反应的蛋白质，而且还是固有免疫细胞（包括皮肤角质形成细胞和气道上皮细胞）的强烈激活剂。HDM 载体或环境衍生的微生物佐剂因子在这种细胞刺激中也起着重要作用。本综述强调了 HDM 过敏原与微生物化合物如何通过模式识别受体依赖性途径促进过敏反应。
