Division of Allergy and Clinical Immunology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Int Arch Allergy Immunol. 2011;155(2):95-105. doi: 10.1159/000320375. Epub 2010 Dec 22.
House dust mite (HDM) represents one of the most common sources of aeroallergens worldwide and more than 50% of allergic patients are sensitized to these allergenic molecules. HDM allergy research in the past has been mainly focused on adaptive, mite allergen-dependent immune responses. In recent years it has become clear that, although the allergen-specific CD4+ Th2 cells orchestrate HDM allergic response,the innate immune system also plays a critical role in HDM-induced allergy pathogenesis. This review will summarize insights into diverse determinants that contribute to the HDM allergenicity through the activation of innate immunity. In addition to the capacity of mite allergens to directly activate mainly skin keratinocytes and airway epithelial cells, innate pattern recognition receptor ligands derived from HDM carriers are also involved in the development of allergic response by HDM.
屋尘螨（HDM）是全世界最常见的过敏原之一，超过 50%的过敏患者对这些变应原分子敏感。过去，HDM 过敏的研究主要集中在适应性、螨变应原依赖的免疫反应上。近年来，人们已经清楚地认识到，尽管过敏原特异性 CD4+Th2 细胞是 HDM 过敏反应的核心，但先天免疫系统在 HDM 诱导的过敏发病机制中也起着关键作用。本综述将总结通过激活先天免疫，导致 HDM 变应原性的不同决定因素的最新认识。除了螨变应原直接激活主要皮肤角质形成细胞和气道上皮细胞的能力外，HDM 载体衍生的先天模式识别受体配体也参与了 HDM 诱导的过敏反应的发生。
