Université de Toulouse, UPS, UMR 5241 Métabolisme, Plasticité et Mitochondrie, BP 84 225, F-31 432 Toulouse Cedex 4, France.
Mitochondrion. 2011 Nov;11(6):862-6. doi: 10.1016/j.mito.2011.06.008. Epub 2011 Jul 1.
It is well-known that mitochondrial volume largely controls mitochondrial functioning. We investigate whether metabolic water produced by oxidative phosphorylation could be involved in mitochondrial volume regulation. We modulated the generation of this water in liver mitochondria and assess their volume by two independent techniques. In liver mitochondria, the mitochondrial volume was specifically decreased when no water was produced independently of energetic parameters and uncoupling activity. In all other conditions associated with water generation, there was no significant change in mitochondrial metabolic volume. Altogether these data demonstrate that mitochondrial volume is regulated, independently of energetic status, by the mitochondrial metabolic water that acts as a signal.
众所周知，线粒体体积在很大程度上控制着线粒体的功能。我们研究了氧化磷酸化产生的代谢水是否参与了线粒体体积的调节。我们调节了肝线粒体中这种水的产生，并通过两种独立的技术来评估它们的体积。在肝线粒体中，当不产生水时，线粒体体积会特异性地减小，而与能量参数和解偶联活性无关。在与水生成相关的所有其他条件下，线粒体代谢体积都没有显著变化。总之，这些数据表明，线粒体体积是由作为信号的线粒体代谢水独立于能量状态来调节的。
