Medical Research Service, Division of Pulmonary and Critical Care Medicine, Department of Medicine, VA Puget Sound Medical Center, University of Washington School of Medicine, Seattle, WA 98108, USA.
Crit Care Clin. 2011 Jul;27(3):735-52. doi: 10.1016/j.ccc.2011.05.013.
Acute lung injury (ALI) involves the activation of multiple pathways leading to lung injury, resolution, and repair. Exploration of the roles of individual pathways in humans and animal models has led to a greater understanding of the complexity of ALI and the links between ALI and systemic multiorgan failure. However, there is still no integrated understanding of the initiation, the progression, and the repair of ALI. A better understanding is needed of how pathways interact in the human ALI syndrome and how complementary treatments can be used to modify the onset, severity, and outcome of ALI in humans.
急性肺损伤（ALI）涉及多条途径的激活，导致肺损伤、恢复和修复。对人类和动物模型中个体途径作用的探索，使人们对 ALI 的复杂性以及 ALI 与全身多器官衰竭之间的联系有了更深入的了解。然而，人们仍然没有综合了解 ALI 的启动、进展和修复。需要更好地了解途径在人类 ALI 综合征中如何相互作用，以及如何使用补充治疗来改变人类 ALI 的发生、严重程度和结果。
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