Fitzgerald N A, Papadimitriou J M, Shellam G R
Department of Microbiology, University of Western Australia, Nedlands.
Arch Virol. 1990;115(1-2):75-88. doi: 10.1007/BF01310624.
Genetically determined resistance to the lethal effects of infection with murine cytomegalovirus (MCMV) has been reported previously in adult and newborn mice. We examined the pathogenesis of MCMV infection in resistant (CBA, H-2k) and susceptible (BALB/c, H-2d) mice infected intraperitoneally on the day of birth. BALB/c mice developed a severe interstitial pneumonitis and myocarditis 10 days post-infection. Their pulmonary and tissues contained high MCMV titres and large numbers of MCMV-antigen positive cells. MCMV also infected the endothelial and myointimal cells of the coronary arteries in newborn BALB/c mice. Only limited infection and pathological changes were seen in CBA mice. Since the severe disease in BALB/c mice resembles the pneumonitis and less frequently reported myocarditis observed after perinatal HCMV infection, the newborn mouse model will be useful for studying the consequences and treatment of such infections, the influence of the host genotype on disease severity and the possible association between perinatal HCMV infection and atherosclerosis.
先前已有报道称，成年和新生小鼠中存在对鼠巨细胞病毒（MCMV）感染致死效应的遗传抗性。我们研究了出生当天经腹腔感染的抗性（CBA，H-2k）和易感（BALB/c，H-2d）小鼠中MCMV感染的发病机制。感染后10天，BALB/c小鼠出现严重的间质性肺炎和心肌炎。它们的肺和组织中含有高滴度的MCMV以及大量MCMV抗原阳性细胞。MCMV还感染了新生BALB/c小鼠冠状动脉的内皮细胞和平滑肌内膜细胞。在CBA小鼠中仅观察到有限的感染和病理变化。由于BALB/c小鼠的严重疾病类似于围产期人巨细胞病毒（HCMV）感染后观察到的肺炎以及较少报道的心肌炎，新生小鼠模型将有助于研究此类感染的后果和治疗、宿主基因型对疾病严重程度的影响以及围产期HCMV感染与动脉粥样硬化之间的可能关联。
